Following is the table of contents to the MedMarket Diligence report #S175, "Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013." The report is described in full here. The report may be purchased online for immediate download or may be ordered via order form.
Table of Contents
|
Executive Summary
|
|
Introduction
|
|
Demographic trends
|
|
Consumer-Driven Product Selection
|
|
Mechanisms of Tissue Repair
|
|
Commercial Imperatives
|
|
Industry Consolidation
|
|
Clinical Caseload
|
|
Market Segmentation and Dynamics
|
|
New Surgical Techniques Drive Market Opportunity
|
|
The Uses of Adjunctive Surgical Closure and Securement Products
|
|
Product Development History
|
|
Evolution of Commercial Markets for Sealants and Adhesives
|
|
Section 1:
|
CLINICAL NEED, CASELOAD, AND PROCEDURE VOLUME
|
|
1.1
|
Anatomy and Physiology of Tissue Repair
|
|
1.2
|
The Skin
|
|
1.3
|
Internal Tissues and Organs
|
|
1.4
|
Wound Classification and Types
|
|
1.4.1
|
Classification by Morphology and Severity
|
|
1.4.2
|
Wound Classification by Cause
|
|
1.4.3
|
Surgical Wounds
|
|
1.5
|
Caseload
|
|
1.5.1
|
Cardiovascular
|
|
1.5.1.1
|
Coronary Heart Disease
|
|
1.5.1.2
|
Dysfunctional Heart Valves
|
|
1.5.1.3
|
Peripheral Vascular Disorders
|
|
1.5.1.4
|
Abnormal Aortic Aneurysms
|
|
1.5.1.5
|
Drivers of Caseloads for Cardiac Surgery
|
|
1.5.2
|
Neurological
|
|
1.5.2.1
|
Stroke
|
|
1.5.2.2
|
Parkinson’s Disease
|
|
1.5.2.3
|
Epilepsy
|
|
1.5.2.4
|
Traumatic Injury
|
|
1.5.2.5
|
Peripheral Nerve Treatment
|
|
1.5.2.6
|
Neurology Drivers
|
|
1.5.3
|
Orthopedic
|
|
1.5.3.1
|
Hip Replacements
|
|
1.5.3.2
|
Knee Replacements
|
|
1.5.3.3
|
Cartilage Repair
|
|
1.5.3.4
|
Ligament Damage
|
|
1.5.3.5
|
Bone Grafting
|
|
1.5.3.6
|
Vertebral Disc Repair
|
|
1.5.3.7
|
Drivers of Orthopedic Surgery
|
|
1.5.4
|
Urological
|
|
1.5.4.1
|
Incontinence
|
|
1.5.4.2
|
Drivers of Urological Surgery
|
|
1.5.5
|
Skin
|
|
1.5.5.1
|
Burns
|
|
1.5.5.2
|
Pressure Ulcers
|
|
1.5.5.3
|
Diabetic Ulcers
|
|
1.5.5.4
|
Venous Ulcers
|
|
1.5.5.5
|
Plastic Surgery
|
|
1.6
|
The Role of Modern Sealant, Securement and Hemostatic Products in Surgery
|
|
1.6.1
|
Fibrin Sealants
|
|
1.6.2
|
High-Strength Glues
|
|
Section 2:
|
SCIENCE, TECHNOLOGY, DEVELOPMENT, CLINICAL AND REGULATORY CHALLENGES
|
|
2.1
|
Tissue Healing
|
|
2.1.1
|
Hemostasis
|
|
2.1.2
|
Proliferation and Maturation
|
|
2.1.3
|
Factors That Affect Healing
|
|
2.2
|
Product Development
|
|
2.3
|
Development Timelines
|
|
2.3.1
|
Collagen and Thrombin Combination
|
|
2.3.2
|
Polyethylene Glycol Polymer (PEG)
|
|
2.3.3
|
Albumin Cross-Linked with Glutaraldehyde
|
|
2.3.4
|
Delivery Systems
|
|
2.4
|
Cost Effectiveness
|
|
2.5
|
Regulatory Challenges
|
|
2.5.1
|
Approval Processes
|
|
2.5.2
|
History of Product Development
|
|
2.5.3
|
Regulatory Aspects
|
|
Section 3:
|
PRODUCTS, TECHNOLOGIES, AND FORECAST OPPORTUNITY
|
|
3.1
|
Overview
|
|
3.2
|
Development Timeline
|
|
3.3
|
Sutures, Staples, and Other Mechanical Closure Devices
|
|
3.3.1
|
Competitors and Products
|
|
3.3.2
|
Suppliers
|
|
3.3.3
|
Product Development
|
|
3.3.4
|
Market Analysis and Forecast
|
|
3.4
|
Tapes
|
|
3.4.1
|
Competitors and Products
|
|
3.4.2
|
Products in Development
|
|
3.4.3
|
Market Analysis and Forecast
|
|
3.5
|
Hemostats
|
|
3.5.1
|
Competitors and Products
|
|
3.5.2
|
Products in Development
|
|
3.5.3
|
Market Analysis and Forecasts
|
|
3.6
|
Fibrin and Other Sealant Products
|
|
3.6.1
|
Competitors and Products
|
|
3.6.2
|
Products in Development
|
|
3.6.3
|
Fibrin and Sealant Market and Competitive Activity
|
|
3.7
|
High-Strength Medical Adhesives
|
|
3.7.1
|
Competitors and Products
|
|
3.7.2
|
Products in Development
|
|
3.7.3
|
Market Analysis and Forecasts
|
|
3.8
|
Post-Surgical Adhesion Prevention
|
|
3.8.1
|
Competitors and Products
|
|
3.8.2
|
Products in Development
|
|
3.8.3
|
Market Analysis and Forecasts
|
|
3.9
|
Wound Closure and Securement Markets: Global and Regional Analysis
|
|
3.9.1
|
Americas
|
|
3.9.1.1
|
United States
|
|
3.9.1.2
|
Latin America
|
|
3.9.2
|
Japan
|
|
3.9.3
|
Europe
|
|
3.9.4
|
Rest of World
|
|
3.10
|
Worldwide Markets By Country and Segment
|
|
Section 4:
|
Company Profiles
|
|
4.1
|
3DM, Inc. (3D-Matrix, Ltd.)
|
|
4.2
|
3M
|
|
4.2.1
|
Products
|
|
4.2.1.1
|
Steri-Strip and Other Wound Closure Products
|
|
4.2.2
|
Financial
|
|
4.3
|
Abbott Vascular
|
|
4.3.1
|
Products
|
|
4.3.1.1
|
Perclose A-T, Perclose ProGlide and Prostar XL
|
|
4.3.1.2
|
StarClose
|
|
4.3.1.3
|
Chito-Seal
|
|
4.3.2
|
Financials
|
|
4.4
|
AccessClosure, Inc.
|
|
4.4.1
|
Product
|
|
4.4.1.1
|
Mynx
|
|
4.5
|
Adhezion Biomedical, LLC
|
|
4.6
|
Advanced Medical Solutions plc
|
|
4.6.1
|
Products
|
|
4.6.1.1
|
LiquiBand
|
|
4.6.2
|
Financials
|
|
4.7
|
Allerderm
|
|
4.8
|
Angiotech Pharmaceuticals, Inc.
|
|
4.8.1
|
Products
|
|
4.8.1.1
|
CoSeal
|
|
4.8.1.2
|
Vitagel
|
|
4.8.1.3
|
Adhibit
|
|
4.8.1.4
|
Quill
|
|
4.8.1.5
|
LOOK Sutures
|
|
4.8.1.6
|
Sharpoint
|
|
4.8.2
|
Financials
|
|
4.9
|
Anika Therapeutics, Inc.
|
|
4.9.1
|
Products
|
|
4.9.1.1
|
Incert-S
|
|
4.9.2
|
Financials
|
|
4.10
|
ARC Pharmaceuticals
|
|
4.10.1
|
Product
|
|
4.10.1.1
|
ARCAD
|
|
4.11
|
Arch Therapeutics, Inc.
|
|
4.12
|
ArthroCare Corporation
|
|
4.12.1
|
Products
|
|
4.12.1.1
|
MagnumWire
|
|
4.12.2
|
Financials
|
|
4.13
|
Aso LLC
|
|
4.14
|
Aspen Surgical Products
|
|
4.15
|
Atrax Medical Group
|
|
4.16
|
Avery Dennison
|
|
4.17
|
B. Braun Melsungen AG
|
|
4.17.1
|
Products
|
|
4.17.1.1
|
Histoacryl
|
|
4.17.1.2
|
Lysostypt
|
|
4.17.1.3
|
Gelita Local Hemostat
|
|
4.17.2
|
Financials
|
|
4.18
|
Bastos Viegas, s.a.
|
|
4.19
|
Baxter International Inc.
|
|
4.19.1
|
Products
|
|
4.19.1.1
|
Tisseel/Tissucol
|
|
4.19.1.2
|
FloSeal
|
|
4.19.1.3
|
CoSeal
|
|
4.19.1.4
|
TissuFleece E
|
|
4.19.1.5
|
ARTISS
|
|
4.19.2
|
Financials
|
|
4.20
|
Bayer HealthCare
|
|
4.21
|
BD (Becton, Dickinson and Company)
|
|
4.21.1
|
Products
|
|
4.21.1.1
|
Autoclip
|
|
4.22
|
Berlin Heart GmbH
|
|
4.22.1
|
Products
|
|
4.22.1.1
|
Gluetiss
|
|
4.23
|
Bernsco Surgical Supply
|
|
4.24
|
Biocoral Inc.
|
|
4.24.1
|
Products
|
|
4.24.1.1
|
Autologous Biological Glue
|
|
4.25
|
BioCore Medical Technologies, Inc.
|
|
4.26
|
Biogentis, Inc.
|
|
4.26.1
|
Products
|
|
4.26.1.1
|
SkinLink
|
|
4.27
|
Biomet Inc.
|
|
4.27.1
|
Product
|
|
4.27.1.1
|
GPS III System
|
|
4.27.1.2
|
Pro Osteon/BioPlex (Interpore Cross)
|
|
4.28
|
BIOSTER a.s.
|
|
4.29
|
BioSyntech Canada Inc.
|
|
4.30
|
BSN Medical
|
|
4.31
|
C.R. Bard
|
|
4.31.1
|
Bard Medical
|
|
4.31.2
|
Davol Inc.
|
|
4.31.3
|
Financials
|
|
4.32
|
Cardiovascular Sciences, Inc.
|
|
4.33
|
Carl Auffarth GmbH & Co. KG
|
|
4.34
|
Cardiva Medical, Inc.
|
|
4.35
|
Ceremed, Inc.
|
|
4.36
|
Chemence Ltd.
|
|
4.37
|
Chemopharma, s.a.
|
|
4.38
|
Cohera Medical, Inc.
|
|
4.38.1
|
Products
|
|
4.38.1.1
|
TissuGlu
|
|
4.39
|
Collagen Matrix, Inc.
|
|
4.39.1
|
Products
|
|
4.39.1.1
|
Porous Collagen Dental Dressings
|
|
4.39.1.2
|
Collatene Fibrillar Collagen Dental Dressing
|
|
4.40
|
Coloplast A/S
|
|
4.41
|
ConvaTec
|
|
4.42
|
Covidien Ltd.
|
|
4.42.1
|
Products
|
|
4.42.1.1
|
DuraSeal
|
|
4.42.1.2
|
SprayGel
|
|
4.42.1.3
|
Indermil (Syneture)
|
|
4.42.1.4
|
PleuraSeal
|
|
4.42.1.5
|
VascuSeal
|
|
4.42.1.6
|
SprayShield
|
|
4.42.2
|
Financials
|
|
4.43
|
CryoLife Inc.
|
|
4.43.1
|
Products
|
|
4.43.1.1
|
BioGlue Surgical Adhesive
|
|
4.43.1.2
|
BioFoam Adhesive
|
|
4.43.1.3
|
Hemostase MPH
|
|
4.43.2
|
Financials
|
|
4.44
|
CSIRO PhotoMedical Technologies
|
|
4.44.1
|
Products
|
|
4.44.1.1
|
PhotoSeal
|
|
4.45
|
CSL Behring
|
|
4.45.1
|
Products
|
|
4.45.1.1
|
Beriplast P Combi-Set (Fibrin Sealant)
|
|
4.45.1.2
|
Beriplex P/N, Confidex
|
|
4.45.1.3
|
Fibrogammin P
|
|
4.45.1.4
|
Haemocomplettan P
|
|
4.45.1.5
|
Kybernin P
|
|
4.46
|
CSMG Technologies, Inc.
|
|
4.46.1
|
Live Tissue Connect, Inc.
|
|
4.47
|
CuraMedical BV
|
|
4.47.1
|
Products
|
|
4.47.1.1
|
Curacel
|
|
4.47.1.2
|
Curacoll
|
|
4.47.1.3
|
Curaspon
|
|
4.48
|
Cypress Medical Products
|
|
4.49
|
Derma Sciences, Inc.
|
|
4.50
|
Distrex Ibérica S.A.
|
|
4.51
|
DuPont Applied BioSciences
|
|
4.52
|
Entegrion, Inc.
|
|
4.52.1
|
Products
|
|
4.52.1.1
|
Stasilon FR
|
|
4.52.1.2
|
Stasix
|
|
4.52.1.3
|
Resusix
|
|
4.53
|
FibroGen, Inc.
|
|
4.54
|
Fidia Advanced Biopolymers
|
|
4.54.1
|
Products
|
|
4.55
|
Flamel Technologies SA
|
|
4.56
|
Forticell Bioscience
|
|
4.56.1
|
Products
|
|
4.56.1.1
|
Fibrin MB
|
|
4.57
|
FzioMed Inc.
|
|
4.57.1
|
Products
|
|
4.57.1.1
|
Oxiplex/SP Gel
|
|
4.57.1.2
|
MediShield
|
|
4.57.1.3
|
Intercoat
|
|
4.57.1.4
|
Laresse Dermal Filler
|
|
4.58
|
Gelita Medical BV
|
|
4.58.1
|
Products
|
|
4.58.1.1
|
Gelita-Spon
|
|
4.58.1.2
|
Gelitacel
|
|
4.58.1.3
|
Geli Putty
|
|
4.59
|
GEM srl
|
|
4.60
|
Genzyme Biosurgery Inc.
|
|
4.60.1
|
Products
|
|
4.60.1.1
|
Sepraflm
|
|
4.60.1.2
|
Seprapack and Sepragel ENT
|
|
4.60.1.3
|
SeprameshIP
|
|
4.60.1.4
|
Epicel
|
|
4.60.1.5
|
FocalSeal
|
|
4.60.2
|
Financial
|
|
4.61
|
GluStitch, Inc.
|
|
4.61.1
|
Products
|
|
4.61.1.1
|
GluStitch
|
|
4.61.1.2
|
GluSeal
|
|
4.61.1.3
|
PeriAcryl
|
|
4.61.1.4
|
GluShield
|
|
4.61.1.5
|
GluSite
|
|
4.62
|
Graceduty Company Limited
|
|
4.63
|
GramsMed, LLC
|
|
4.64
|
Haemacure Corporation
|
|
4.64.1
|
Products
|
|
4.64.1.1
|
Hemaseel HMN
|
|
4.64.1.2
|
Hemaseel Thrombin
|
|
4.64.2
|
Financial Data
|
|
4.65
|
HAPTO Biotech Israel Ltd.
|
|
4.66
|
Hartmann Group
|
|
4.67
|
Harvest Technologies Corporation
|
|
4.68
|
HemCon Medical Technologies, Inc.
|
|
4.68.1
|
Products
|
|
4.68.1.1
|
HemCon Bandage
|
|
4.68.1.2
|
ChitoFlex
|
|
4.68.1.3
|
HemCon Dental Dressing
|
|
4.68.1.4
|
KytoStat
|
|
4.68.1.5
|
m•doc
|
|
4.69
|
Hemostasis, LLC
|
|
4.70
|
HyperBranch Medical Technology, Inc.
|
|
4.71
|
Incisive Surgical, Inc.
|
|
4.72
|
Innovasa Corporation
|
|
4.73
|
Integra Lifesciences Corporation
|
|
4.73.1
|
Products
|
|
4.73.2
|
Financials
|
|
4.74
|
I-Therapeutix, Inc.
|
|
4.75
|
Johnson & Johnson
|
|
4.75.1
|
Ethicon, Inc. and Ethicon Endo-Surgery, Inc.
|
|
4.75.1.1
|
Evicel/Quixil
|
|
4.75.1.2
|
Dermabond
|
|
4.75.1.3
|
Omnex
|
|
4.75.1.4
|
Gynecare Interceed
|
|
4.75.1.5
|
Hemostasis Products
|
|
4.75.1.6
|
Surgical Sutures and Skin Closures
|
|
4.75.2
|
DePuy Spine
|
|
4.75.3
|
Financials
|
|
4.76
|
Kaketsuken (Chemo-Sero-Therapeutic Research Institute)
|
|
4.77
|
Kensey Nash Corporation
|
|
4.77.1
|
Product
|
|
4.77.1.1
|
Angio-Seal
|
|
4.78
|
Kimberly-Clark Health Care
|
|
4.78.1
|
Products
|
|
4.78.1.1
|
InteguSeal
|
|
4.78.2
|
Financials
|
|
4.79
|
Kinetic Concepts, Inc.
|
|
4.80
|
King Pharmaceuticals, Inc.
|
|
4.80.1
|
Products
|
|
4.80.1.1
|
Thrombin-JMI
|
|
4.80.2
|
Financials
|
|
4.81
|
Kookbo Chemicals Co., Ltd. (KB Chem.)
|
|
4.82
|
Laboratoires Urgo (Urgo Medical)
|
|
4.83
|
Lewis Medical Supplies
|
|
4.84
|
LifeBond Ltd.
|
|
4.85
|
Lifecore Biomedical, Inc.
|
|
4.86
|
Lohmann & Rauscher
|
|
4.87
|
Marine Polymer Technologies
|
|
4.88
|
Medafor, Inc.
|
|
4.89
|
Medi Surgichem Pvt. Ltd.
|
|
4.90
|
MedTrade Products, Ltd.
|
|
4.91
|
Meyer-Haake GmbH Medical Innovations
|
|
4.92
|
Mölnlycke Health Care AB
|
|
4.93
|
Morris Innovative
|
|
4.94
|
Motex Healthcare Corp.
|
|
4.95
|
Myco Medical
|
|
4.96
|
NeatStitch Ltd.
|
|
4.97
|
Neose Technologies Inc. (Novo Nordisk)
|
|
4.98
|
Nycomed
|
|
4.98.1
|
Products
|
|
4.99
|
Omrix Biopharmaceuticals Inc.
|
|
4.99.1
|
Products
|
|
4.99.1.1
|
Evicel/Quixil
|
|
4.99.1.2
|
Fibrin Patch
|
|
4.99.1.3
|
Evithrom
|
|
4.99.1.4
|
Adhexil
|
|
4.99.2
|
Financials
|
|
4.100
|
Pac-Kit Safety Equipment
|
|
4.101
|
Pfizer Inc.
|
|
4.101.1
|
Product
|
|
4.101.1.1
|
Gelfoam
|
|
4.101.2
|
Financials
|
|
4.102
|
Pharming Group NV
|
|
4.102.1
|
Financials
|
|
4.103
|
Plasma Technologies, Inc.
|
|
4.104
|
PlasmaSeal
|
|
4.105
|
Pluromed, Inc.
|
|
4.106
|
Polyganics
|
|
4.107
|
Polyheal Ltd.
|
|
4.108
|
ProFibrix BV
|
|
4.109
|
Progressive Surgical, Ltd.
|
|
4.110
|
Protein Polymer Technologies, Inc.
|
|
4.111
|
Radi Medical Systems AB
|
|
4.111.1
|
Products
|
|
4.111.1.1
|
FemoSeal
|
|
4.112
|
Resorba Wundversorgung GmbH & Co. KG
|
|
4.113
|
Scapa Group plc
|
|
4.114
|
Scion Cardio-Vascular, Inc.
|
|
4.115
|
Sea Run Holdings
|
|
4.116
|
Seton
|
|
4.117
|
Smith & Nephew plc
|
|
4.118
|
Starch Medical, Inc.
|
|
4.118.1
|
Products
|
|
4.118.1.1
|
PerClot
|
|
4.118.1.2
|
StarFoam
|
|
4.118.1.3
|
SuperClot
|
|
4.119
|
Steroplast Ltd.
|
|
4.120
|
Sutura, Inc.
|
|
4.120.1
|
Products
|
|
4.120.1.1
|
SuperStitch
|
|
4.121
|
Synovis Life Technologies
|
|
4.122
|
SyntheMed, Inc.
|
|
4.123
|
Teleflex Medical
|
|
4.123.1
|
Products
|
|
4.123.1.1
|
Deknatel Sutures
|
|
4.123.1.2
|
Weck
|
|
4.123.2
|
Financial
|
|
4.124
|
ThermoGenesis Corporation
|
|
4.124.1
|
Products
|
|
4.124.1.1
|
CryoSeal FS System
|
|
4.124.1.2
|
Thrombin Processing Device (TPD)
|
|
4.125
|
Therus Corporation
|
|
4.126
|
Thrombotargets Corp.
|
|
4.126.1
|
Products
|
|
4.126.1.1
|
TT-103MH
|
|
4.127
|
Tissuemed Ltd.
|
|
4.127.1
|
Products
|
|
4.128
|
TraumaCure, Inc.
|
|
4.128.1
|
Products
|
|
4.128.1.1
|
WoundStat
|
|
4.129
|
TyRx Pharma Inc.
|
|
4.130
|
Vascular Solutions, Inc.
|
|
4.131
|
Vectura Group plc
|
|
4.131.1
|
Product
|
|
4.131.1.1
|
Adept
|
|
4.132
|
Vivostat A/S
|
|
4.132.1
|
Products
|
|
4.132.1.1
|
Vivostat
|
|
4.133
|
Z-Medica Corporation
|
|
4.134
|
Zimmer
|
|
4.135
|
ZymoGenetics, Inc.
|
|
4.135.1
|
Products
|
|
4.135.1.1
|
Recothrom
|
|
4.135.2
|
Financials
|
|
|
|
|
Appendix
|
List of Companies
|
List of Exhibits
|
Section #
|
Section heading
|
|
Exhibit ES-1
|
Recent Acquisitions in the Securement Segment
|
|
Exhibit ES-2
|
Introducers of New Securement Technologies to the U.S. Market
|
|
Exhibit ES-3
|
Definition of Surgical Closure and Securement Products
|
|
Exhibit ES-4
|
Incidence of Two Example Surgical Procedures with High Requirement for Adjunctive Products for Surgical Closure and Securement
|
|
Exhibit ES-5
|
U.S. FDA Approved Uses of Sealants, Glues, and Hemostats
|
|
Exhibit ES-6
|
Synthetic and Biological Sealant Competitors (Non-Fibrin Sealants)
|
|
Exhibit ES-7
|
Selected High-Strength Adhesive Companies and Their Strategies
|
|
Exhibit ES-8
|
Selected Sealant Product Companies and Their Strategies
|
|
Exhibit ES-9
|
Worldwide Growth in the Securement and Closure Market, 2006–2013
|
|
Exhibit 1-1
|
Skin Structure Illustrating Major Organelles and Skin Layers
|
|
Exhibit 1-2
|
Classification of Wounds by Morphology
|
|
Exhibit 1-3
|
Severity Classification of Wounds
|
|
Exhibit 1-4
|
Wound Classification by Etiology
|
|
Exhibit 1-5
|
Prevalence of Different Wound Types, 2008
|
|
Exhibit 1-6
|
Criteria for Adjunctive Use of Hemostats, Sealants, Glues and Adhesion Prevention Products in Surgery
|
|
Exhibit 1-7
|
Surgical Procedures with Potential for the Use of Hemostats, Sealants, Glues and Adhesion Prevention Products, Worldwide
|
|
Exhibit 1-8
|
Potential for Cardiovascular Applications, Prevalence of Applicable Surgical Applications
|
|
Exhibit 1-9
|
Potential for Neurological Applications, Prevalence of Applicable Disorders
|
|
Exhibit 1-10
|
Potential for Orthopedic Applications, Frequency of Major Surgical Interventions
|
|
Exhibit 1-11
|
Potential for Urological Applications, Prevalence of Applicable Disorders
|
|
Exhibit 1-12
|
Potential for Dermal Repair, Prevalence of Applicable Disorders
|
|
Exhibit 1-13
|
Applications of Fibrin and Other Sealants
|
|
Exhibit 1-14
|
Surgical Procedures Using Fibrin and Other Sealant Products (2009–2013)
|
|
Exhibit 1-15
|
Surgical Indications for High-Strength Glues (Europe, 2008)
|
|
Exhibit 2-1
|
Factors That Affect Wound Healing
|
|
Exhibit 2-2
|
Timescales for Development of Closure and Sealant Products
|
|
Exhibit 2-3
|
Variables Associated With Clinical Evaluation of Closure and Securement and Related Products
|
|
Exhibit 3-1
|
Manufacturers of Surgical Sutures, Staples, Clips, and Other Mechanical Closure Devices
|
|
Exhibit 3-2
|
Worldwide Sutures and Staples Market Forecast, 2006–2013
|
|
Exhibit 3-3
|
Worldwide Suture and Staples Market 2007, Share by Supplier
|
|
Exhibit 3-4
|
Companies Commercializing First Aid Technologies Often Used as Tapes for Closure
|
|
Exhibit 3-5
|
Worldwide Tapes Market Forecast, 2006-2013
|
|
Exhibit 3-6
|
Worldwide Tapes for Closure Market Share, 2007, by Supplier
|
|
Exhibit 3-7
|
Companies Commercializing Technologies in the Hemostat Category
|
|
Exhibit 3-8
|
Worldwide Hemostats Market Forecast, 2009–2013
|
|
Exhibit 3-9
|
Worldwide Hemostats Market Share, 2007, by Supplier
|
|
Exhibit 3-10
|
Companies Commercializing Technologies in the Sealants Category
|
|
Exhibit 3-11
|
Worldwide Sealants Market Forecast, 2006-2013
|
|
Exhibit 3-12
|
Worldwide Sealants Market Share, 2007, by Supplier
|
|
Exhibit 3-13
|
Companies Commercializing Cyanoacrylate-based High-Strength Medical Adhesives
|
|
Exhibit 3-14
|
Worldwide High-Strength Glues Market Forecast, 2006–2013
|
|
Exhibit 3-15
|
Worldwide High-Strength Glues Market Share 2007, by Supplier
|
|
Exhibit 3-16
|
Companies Commercializing Technologies in the Post-Surgical Adhesion Prevention Category
|
|
Exhibit 3-17
|
Worldwide Post-Operative Adhesion Prevention Market Forecast, 2006–2013
|
|
Exhibit 3-18
|
Worldwide Post Operative Adhesion Prevention Market Share, 2007, by Supplier
|
|
Exhibit 3-19
|
Size and Growth of Wound Closure and Securement Market, World and Selected Countries, 2007
|
|
Exhibit 3-20
|
Wound Closure Market 2007, by Product Segments, The Major American Countries
|
|
Exhibit 3-21
|
Wound Closure Market 2007, by Product Segments, Japan
|
|
Exhibit 3-22
|
Wound Closure Market 2007, by Product Segments, Major European Countries
|
|
Exhibit 3-23
|
Wound Closure Market 2007, by Product Segments, Rest of World
|
|
Exhibit 3-24
|
Growth Forecast for Closure and Securement Market, 2006–2013
|
|
Exhibit 4-1
|
3M, Selected Financial Data for 2007
|
|
Exhibit 4-2
|
Abbott Laboratories, Selected Financial Data for the First Nine Months of 2008
|
|
Exhibit 4-3
|
Advanced Medical Solutions’ Selected Financial Data for 2006 and 2007
|
|
Exhibit 4-4
|
Angiotech Pharmaceuticals’ Statement of Income for 2nd Quarter, 2008 (Ending June 30)
|
|
Exhibit 4-5
|
Anika Therapeutics’ Financial Results for 2006 and 2007
|
|
Exhibit 4-6
|
ArthroCare Corporation Financial Data
|
|
Exhibit 4-7
|
B. Braun Financial Data
|
|
Exhibit 4-8
|
Baxter International Financial Data
|
|
Exhibit 4-9
|
C.R. Bard, Inc. Financial Data for Nine Months Ending Sept. 30
|
|
Exhibit 4-10
|
Cardiovascular Sciences, Inc. Financial Data
|
|
Exhibit 4-11
|
Covidien, Selected Financial Data, 2007
|
|
Exhibit 4-12
|
CryoLife Financial Results, 2006 and 2007
|
|
Exhibit 4-13
|
Haemacure Corporation, Selected Financial Data
|
|
Exhibit 4-14
|
Integra Lifesciences, Financial Data
|
|
Exhibit 4-15
|
Johnson & Johnson Key Financial Data, 2006 and 2007
|
|
Exhibit 4-16
|
Kimberly-Clark Health Care Financial Data
|
|
Exhibit 4-17
|
King Pharmaceuticals Financial Data
|
|
Exhibit 4-18
|
Overview of Omrix’ Biosurgical Product Pipeline
|
|
Exhibit 4-19
|
Omrix Biopharmaceuticals Financial Data
|
|
Exhibit 4-20
|
Pfizer Financial Data for 2007 and 2006
|
|
Exhibit 4-21
|
Pharming Financial Data
|
|
Exhibit 4-22
|
Teleflex Inc. Financial Data
|
|
Exhibit 4-23
|
Vascular Solutions Financial Results
|
|
Exhibit 4-24
|
ZymoGenetics Financial Data, 3rd Quarter, 2008
|
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Worldwide Surgical Sealants, Glues, Wound Closure and Ant-Adhesion Markets, 2009-2013
