Comments on: Stent shapes, designs and impact on restenosis, other complications http://mediligence.com/blog/2009/07/17/stent-shapes-designs-and-impact-on-restenosis-other-complications/ insights, perspectives and inside data from the founder of MMD Wed, 10 Mar 2010 22:43:46 +0000 http://wordpress.org/?v=2.9.2 hourly 1 By: drkparikh http://mediligence.com/blog/2009/07/17/stent-shapes-designs-and-impact-on-restenosis-other-complications/comment-page-1/#comment-3619 drkparikh Sat, 18 Jul 2009 15:00:36 +0000 http://mediligence.com/blog/?p=1654#comment-3619 The strut thickness was a parameter which was a consideration for the BMS, but for DES apart from the stent the other important parameter is Polymer. It is a known fact that all the first generation DES are having the stable polymer which stays inside the body and it has been found to be the culprit behind the late and very late stent thrombosis by causing inflammation. The latest trend is to have a biodegradable polymer along with low strut thickness and in this there are quiet a few companies which have done quite a lot of research.<br>1. Sahajanand Medical Technologies , <a href="http://www.smtpl.com" rel="nofollow">www.smtpl.com</a> are the pioneers in this technology. Infinnium- paclitaxel eluting stent was the first to have a blend of biodegradable polymers. Infinnium infact happens to be the 1st stent with biodegradable polymers to get the CE approval. SMTPL has 3 more DES and all are with biodegradable polymers. many publications of SMTPLs DES shows consistent low Mace rates and Low Stent thrombosis Rates<br>2. Biosensors also has the Biomatrix stent with PLA as the biodegradable polymer. But Pla alone is not enough as the polymer is not very elastic and develops cracks easily and hence the chance of non uniform distribution of drug.<br>3. Termuo also has the NOBORI stent with just the Pla biodegradable polymer<br>4. JMD has the Excel stent with just the PLA biodegradable polymer.<br><br>the future can also see the success development of BIODEGRADABLE STENT. But this technology looks to be far away till that time Biodegradable polymer based DES will rule the market The strut thickness was a parameter which was a consideration for the BMS, but for DES apart from the stent the other important parameter is Polymer. It is a known fact that all the first generation DES are having the stable polymer which stays inside the body and it has been found to be the culprit behind the late and very late stent thrombosis by causing inflammation. The latest trend is to have a biodegradable polymer along with low strut thickness and in this there are quiet a few companies which have done quite a lot of research.
1. Sahajanand Medical Technologies , http://www.smtpl.com are the pioneers in this technology. Infinnium- paclitaxel eluting stent was the first to have a blend of biodegradable polymers. Infinnium infact happens to be the 1st stent with biodegradable polymers to get the CE approval. SMTPL has 3 more DES and all are with biodegradable polymers. many publications of SMTPLs DES shows consistent low Mace rates and Low Stent thrombosis Rates
2. Biosensors also has the Biomatrix stent with PLA as the biodegradable polymer. But Pla alone is not enough as the polymer is not very elastic and develops cracks easily and hence the chance of non uniform distribution of drug.
3. Termuo also has the NOBORI stent with just the Pla biodegradable polymer
4. JMD has the Excel stent with just the PLA biodegradable polymer.

the future can also see the success development of BIODEGRADABLE STENT. But this technology looks to be far away till that time Biodegradable polymer based DES will rule the market

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