· 322 pages
· 75 Exhibits
· 136 Company Profiles
· Report #S175
· Published January 2009
This report details the complete range of sealants &
glues technologies used in traumatic, surgical and other wound closure, from tapes, sutures and staples to hemostats, fibrin
sealants/glues and medical adhesives. The report details current clinical and
technology developments in this huge and rapidly growing worldwide
market, with data on products in development and on the market; market size and
forecast; competitor market shares; competitor profiles; and market
opportunity.
This report is a
market and technology assessment and forecast of surgical sealants,
glues, hemostasis, other wound
closure and anti-adhesion. The report details the current and emerging products,
technologies and markets involved in wound closure and sealing using
sutures and staples, tapes, hemostats, fibrin and sealant products, medical adhesives
and products to prevent surgical adhesions. The report provides a worldwide current and annual
forecast to 2013 of the markets for these technologies, with particular
emphasis on the market impact of new technologies through the coming
decade. The report provides specific forecasts and shares of the
worldwide market by segment for
the U.S., Europe (United Kingdom, German, France, Italy, BeNeLux), Latin
America, Japan and Rest of World.
The report provides
background data on the surgical, disease and traumatic wound patient
populations targeted by current technologies and those under
development, and the current clinical practices in the management of
these patients, including the dynamics among the various clinical
specialties or subspecialties vying for patient population and
facilitating or limiting the growth of technologies.
The report
establishes the current worldwide market size for major technology
segments as a baseline for and projecting growth in the market over a
ten-year forecast. The report also assesses and projects the composition
of the market as technologies gain or lose relative market performance
over this period.
Table of
Contents
Executive Summary
Introduction
Demographic trends
Consumer-Driven Product Selection
Mechanisms of Tissue Repair
Commercial Imperatives
Industry Consolidation
Clinical Caseload
Market Segmentation and Dynamics
New Surgical Techniques Drive Market
Opportunity
The Uses of Adjunctive Surgical Closure and
Securement Products
Product Development History
Evolution of Commercial Markets for Sealants
and Adhesives
Company Strategies — Overview
Section 1: CLINICAL NEED, CASELOAD, AND PROCEDURE VOLUME
1.1 Anatomy and Physiology of Tissue
Repair
1.2 The Skin
1.3 Internal Tissues and Organs
1.4 Wound Classification and Types
1.4.1 Classification by Morphology
and Severity
1.4.2 Wound Classification by Cause
1.4.3 Surgical Wounds
1.5 Caseload
1.5.1 Cardiovascular
1.5.1.1 Coronary Heart Disease
1.5.1.2 Dysfunctional Heart
Valves
1.5.1.3 Peripheral Vascular
Disorders
1.5.1.4 Abnormal Aortic Aneurysms
1.5.1.5 Drivers of Caseloads for
Cardiac Surgery
1.5.2 Neurological
1.5.2.1 Stroke
1.5.2.2 Parkinson’s Disease
1.5.2.3 Epilepsy
1.5.2.4 Traumatic Injury
1.5.2.5 Peripheral Nerve
Treatment
1.5.2.6 Neurology Drivers
1.5.3 Orthopedic
1.5.3.1 Hip Replacements
1.5.3.2 Knee Replacements
1.5.3.3 Cartilage Repair
1.5.3.4 Ligament Damage
1.5.3.5 Bone Grafting
1.5.3.6 Vertebral Disc Repair
1.5.3.7 Drivers of Orthopedic
Surgery
1.5.4 Urological
1.5.4.1 Incontinence
1.5.4.2 Drivers of Urological
Surgery
1.5.5 Skin
1.5.5.1 Burns
1.5.5.2 Pressure Ulcers
1.5.5.3 Diabetic Ulcers
1.5.5.4 Venous Ulcers
1.5.5.5 Plastic Surgery
1.6 The Role of Modern Sealant,
Securement and Hemostatic Products in Surgery
1.6.1 Fibrin Sealants
1.6.2 High-Strength Glues
Section 2: SCIENCE, TECHNOLOGY, DEVELOPMENT, CLINICAL AND REGULATORY
CHALLENGES
2.1 Tissue Healing
2.1.1 Hemostasis
2.1.2 Proliferation and Maturation
2.1.3 Factors That Affect Healing
2.2 Product Development
2.3 Development Timelines
2.3.1 Collagen and Thrombin
Combination
2.3.2 Polyethylene Glycol Polymer
(PEG)
2.3.3 Albumin Cross-Linked with
Glutaraldehyde
2.3.4 Delivery Systems
2.4 Cost Effectiveness
2.5 Regulatory Challenges
2.5.1 Approval Processes
2.5.2 History of Product Development
2.5.3 Regulatory Aspects
Section 3: PRODUCTS, TECHNOLOGIES, AND FORECAST OPPORTUNITY
3.1 Overview
3.2 Development Timeline
3.3 Sutures, Staples, and Other
Mechanical Closure Devices
3.3.1 Competitors and Products
3.3.2 Suppliers
3.3.3 Product Development
3.3.4 Market Analysis and Forecast
3.4 Tapes
3.4.1 Competitors and Products
3.4.2 Products in Development
3.4.3 Market Analysis and Forecast
3.5 Hemostats
3.5.1 Competitors and Products
3.5.2 Products in Development
3.5.3 Market Analysis and Forecasts
3.6 Fibrin and Other Sealant Products
3.6.1 Competitors and Products
3.6.2 Products in Development
3.6.3 Fibrin and Sealant Market and
Competitive Activity
3.7 High-Strength Medical Adhesives
3.7.1 Competitors and Products
3.7.2 Products in Development
3.7.3 Market Analysis and Forecasts
3.8 Post-Surgical Adhesion Prevention
3.8.1 Competitors and Products
3.8.2 Products in Development
3.8.3 Market Analysis and Forecasts
3.9 Wound Closure and Securement Markets:
Global and Regional Analysis
3.9.1 Americas
3.9.1.1 United States
3.9.1.2 Latin America
3.9.2 Japan
3.9.3 Europe
3.9.4 Rest of World
3.10 Worldwide Markets By Country and
Segment
Section 4: Company Profiles
4.1 3DM, Inc. (3D-Matrix, Ltd.)
4.2 3M
4.3 Abbott Vascular
4.4 AccessClosure, Inc.
4.5 Adhezion Biomedical, LLC
4.6 Advanced Medical Solutions plc
4.7 Allerderm
4.8 Angiotech Pharmaceuticals, Inc.
4.9 Anika Therapeutics, Inc.
4.10 ARC Pharmaceuticals
4.11 Arch Therapeutics, Inc.
4.12 ArthroCare Corporation
4.13 Aso LLC
4.14 Aspen Surgical Products
4.15 Atrax Medical Group
4.16 Avery Dennison
4.17 B. Braun Melsungen AG
4.18 Bastos Viegas, s.a.
4.19 Baxter International Inc.
4.20 Bayer HealthCare
4.21 BD (Becton, Dickinson and
Company)
4.22 Berlin Heart GmbH
4.23 Bernsco Surgical Supply
4.24 Biocoral Inc.
4.25 BioCore Medical Technologies,
Inc.
4.26 Biogentis, Inc.
4.27 Biomet Inc.
4.28 BIOSTER a.s.
4.29 BioSyntech Canada Inc.
4.30 BSN Medical
4.31 C.R. Bard
4.32 Cardiovascular Sciences, Inc.
4.34 Carl Auffarth GmbH & Co. KG
4.35 Cardiva Medical, Inc.
4.36 Ceremed, Inc.
4.37 Chemence Ltd.
4.38 Chemopharma, s.a.
4.39 Cohera Medical, Inc.
4.40 Collagen Matrix, Inc.
4.41 Coloplast A/S
4.42 ConvaTec
4.43 Covidien Ltd.
4.44 CryoLife Inc.
4.45 CSIRO PhotoMedical Technologies
4.46 CSL Behring
4.47 CSMG Technologies, Inc.
4.48 CuraMedical BV
4.49 Cypress Medical Products
4.50 Derma Sciences, Inc.
4.51 Distrex Ibérica S.A.
4.52 DuPont Applied BioSciences
4.53 Entegrion, Inc.
4.54 FibroGen, Inc.
4.55 Fidia Advanced Biopolymers
4.56 Flamel Technologies SA
4.57 Forticell Bioscience
4.58 FzioMed Inc.
4.59 Gelita Medical BV
4.60 GEM srl
4.61 Genzyme Biosurgery Inc.
4.62 GluStitch, Inc.
4.63 Graceduty Company Limited
4.64 GramsMed, LLC
4.65 Haemacure Corporation
4.66 HAPTO Biotech Israel Ltd.
4.67 Hartmann Group
4.68 Harvest Technologies Corporation
4.69 HemCon Medical Technologies,
Inc.
4.70 Hemostasis, LLC
4.71 HyperBranch Medical Technology,
Inc.
4.72 Incisive Surgical, Inc.
4.73 Innovasa Corporation
4.74 Integra Lifesciences Corporation
4.75 I-Therapeutix, Inc.
4.76 Johnson & Johnson (Ethicon,
Ethicon Endo-Surgery, DePuy Spine)
4.77 Kaketsuken (Chemo-Sero-Therapeutic
Research Institute)
4.78 Kensey Nash Corporation
4.79 Kimberly-Clark Health Care
4.80 Kinetic Concepts, Inc.
4.81 King Pharmaceuticals, Inc.
4.82 Kookbo Chemicals Co., Ltd. (KB
Chem.)
4.83 Laboratoires Urgo (Urgo Medical)
4.84 Lewis Medical Supplies
4.85 LifeBond Ltd.
4.86 Lifecore Biomedical, Inc.
4.87 Lohmann & Rauscher
4.88 Marine Polymer Technologies
4.89 Medafor, Inc.
4.90 Medi Surgichem Pvt. Ltd.
4.91 MedTrade Products, Ltd.
4.92 Meyer-Haake GmbH Medical
Innovations
4.93 Mölnlycke Health Care AB
4.94 Morris Innovative
4.95 Motex Healthcare Corp.
4.96 Myco Medical
4.97 NeatStitch Ltd.
4.98 Neose Technologies Inc. (Novo
Nordisk)
4.99 Nycomed
.100 Omrix Biopharmaceuticals Inc.
4.101 Pac-Kit Safety Equipment
4.102 Pfizer Inc.
4.103 Pharming Group NV
4.104 Plasma Technologies, Inc.
4.105 PlasmaSeal
4.106 Pluromed, Inc.
4.107 Polyganics
4.108 Polyheal Ltd.
4.109 ProFibrix BV
4.110 Progressive Surgical, Ltd.
4.111 Protein Polymer Technologies,
Inc.
4.112 Radi Medical Systems AB
4.113 Resorba Wundversorgung GmbH & Co.
KG
4.114 Scapa Group plc
4.115 Scion Cardio-Vascular, Inc.
4.116 Sea Run Holdings
4.117 Seton
4.118 Smith & Nephew plc
4.119 Starch Medical, Inc.
4.120 Steroplast Ltd.
4.121 Sutura, Inc.
4.122 Synovis Life Technologies
4.123 SyntheMed, Inc.
4.124 Teleflex Medical
4.125 Tenaxis Medical, Inc.
4.126 ThermoGenesis Corporation
4.127 Therus Corporation
4.128 Thrombotargets Corp.
4.129 Tissuemed Ltd.
4.130 TraumaCure, Inc.
4.131 TyRx Pharma Inc.
4.132 Vascular Solutions, Inc.
4.133 Vectura Group plc
4.134 Vivostat A/S
4.135 Z-Medica Corporation
4.136 Zimmer
4.137 ZymoGenetics, Inc.
APPENDIX: LIST OF COMPANIES
List of Exhibits
Exhibit ES-1: Recent Acquisitions in the
Securement Segment
Exhibit ES-2: Introducers of New Securement
Technologies to the U.S. Market
Exhibit ES-3: Definition of Surgical Closure and
Securement Products
Exhibit ES-4: Incidence of Two Example Surgical
Procedures with High Requirement for Adjunctive Products for Surgical Closure
and Securement
Exhibit ES-5: U.S. FDA Approved Uses of Sealants,
Glues, and Hemostats
Exhibit ES-6: Synthetic and Biological Sealant
Competitors (Non-Fibrin Sealants)
Exhibit ES-7: Selected High-Strength Adhesive
Companies and Their Strategies
Exhibit ES-8: Selected Sealant Product Companies
and Their Strategies
Exhibit ES-9: Worldwide Growth in the Securement
and Closure Market, 2006–2013
Exhibit 1-1: Skin Structure Illustrating Major
Organelles and Skin Layers
Exhibit 1-2: Classification of Wounds by
Morphology
Exhibit 1-3: Severity Classification of Wounds
Exhibit 1-4: Wound Classification by Etiology
Exhibit 1-5: Prevalence of Different Wound Types,
2008
Exhibit 1-6: Criteria for Adjunctive Use of
Hemostats, Sealants, Glues and Adhesion Prevention Products in Surgery
Exhibit 1-7: Surgical Procedures with Potential
for the Use of Hemostats, Sealants, Glues and Adhesion Prevention Products,
Worldwide
Exhibit 1-8: Potential for Cardiovascular
Applications, Prevalence of Applicable Surgical Applications
Exhibit 1-9: Potential for Neurological
Applications, Prevalence of Applicable Disorders
Exhibit 1-10: Potential for Orthopedic
Applications, Frequency of Major Surgical Interventions
Exhibit 1-11: Potential for Urological
Applications, Prevalence of Applicable Disorders
Exhibit 1-12: Potential for Dermal Repair,
Prevalence of Applicable Disorders
Exhibit 1-13: Applications of Fibrin and Other
Sealants
Exhibit 1-14: Surgical Procedures Using Fibrin
and Other Sealant Products (2009–2013)
Exhibit 1-15: Surgical Indications for
High-Strength Glues (Europe, 2008)
Exhibit 2-1: Factors That Affect Wound Healing
Exhibit 2-2: Timescales for Development of
Closure and Sealant Products
Exhibit 2-3: Variables Associated With Clinical
Evaluation of Closure and Securement and Related Products
Exhibit 3-1: Manufacturers of Surgical Sutures,
Staples, Clips, and Other Mechanical Closure Devices
Exhibit 3-2: Worldwide Sutures and Staples Market
Forecast, 2009–2013
Exhibit 3-3: Worldwide Suture and Staples Market
2007, Share by Supplier
Exhibit 3-4: Companies Commercializing First Aid
Technologies Often Used as Tapes for Closure
Please note
that we have covered, in our "advanced medical technologies" blog, the full
range of sealants, glues, wound closure and anti-adhesion products and
technologies extensively and have drawn from the report for plenty of examples.
To see all of those posts, go to this
link. If you have any questions, free
to contact me and I'll be happy to answer any of your questions about the
report.
Patrick Driscoll
tel: +1.949.859.3401
tel: +1.949.891.1753 (google voice)
Methodology. MedMarket Diligence Reports are
produced through primary and secondary research. Data is gathered from
published sources on products and technologies on the market and under
development. Clinicians and industry representatives are
interviewed for their knowledge and insights on product development,
market development, clinical practice and trends associated with the
evolving use of technologies. Secondary data is used to corroborate
and support assessments and projections. Reports are written and
researched by industry insiders, whose familiarity with the companies,
industry dynamics and other marketplace specifics facilitate the
research process and ensure high quality and thorough reports.
Contact: Patrick Driscoll, (949) 859-3401. patrick<at>mediligence<dot>com.
