Markets and Recent Developments in Medical Technologies, from MedMarket Diligence, LLC

Ablation technologies proliferate from their many clinical benefits

pjd@mediligence.com (Patrick Driscoll) — Mon, 29 Jun 2009 23:18:19 -0700

Ablation technologies are a surprisingly diverse group of treatments that have multiple clinical applications, but all have the potential to compete with each other, and most have significant existing markets, growth rates or both. The advanced medical technologies blog highlights the growth versus market size balance for the different ablation modalities.

Ablation technologies and their worldwide markets are subject of the market report from MedMarket Diligence report #A125.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: ablation, rf ablation, microwave, ultrasound, HIFU, laser, radiation, thermal ablation, electrosurgery.

Novel coronary stent technologies

pjd@mediligence.com (Patrick Driscoll) — Mon, 29 Jun 2009 00:04:45 -0700

Competitors in the market for the treatment of coronary artery disease must face a litany of alternative technologies targeted at this patient caseload. In stents alone, there are multiple variants of coating types (or none) and materials on the market and in development. The advanced medical technologies blog, drawing on the MedMarket Diligence global stent market report #C245, highlights the range of these novel stent technologies .

MedMarket Diligence has recently published (May 2009) report #C245, "Worldwide Coronary Stents Market, 2008-2017". The report may be purchased for immediate download online or may be ordered via order form.

Tags: stents, drug eluting, drug-coated, angioplasty, PTCA

Worldwide Market: Surgical Sealants and Glues (plus hemostasis, anti-adhesion)

patrick@mediligence.com — Sat, 27 Jun 2009 10:31:26 -0700

The advanced medical technologies blog highlights the global opportunities for products in surgical securement (surgical sealants, glues, other wound closure, hemostasis, and anti-adhesion), drawn from the worldwide surgical sealants, glues and wound closure report from MedMarket Diligence (report #S175).

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: surgical sealant, surgical glue, fibrin sealant, fibrin glue, medical glue, medical adhesive, anti-adhesion

Coronary stent unit volume size, growth, by stent type

pjd@mediligence.com (Patrick Driscoll) — Sat, 27 Jun 2009 10:15:21 -0700

Size and growth rates in the unit volume sales of coronary stents vary by stent type: drug-eluting, bare metal and bioabsorbable stents. The advanced medical technologies blog, drawing on the MedMarket Diligence global stent market report #C245, graphically illustrates this.

Ablation technologies and their variable penetration of clinical applications

pjd@mediligence.com (Patrick Driscoll) — Tue, 16 Jun 2009 22:43:28 -0700

Applications of ablation technologies --- the use of energy-based and other modalities that cut, burn, freeze, vaporize or otherwise therapeutically destroy tissue -- have penetrated numerous clinical applications, but that penetration varies by modality and clinical application. The advanced medical technologies blog highlights the variable penetration of ablation technologies for treatment of cancer.

Ablation technologies and their worldwide markets are subject of the market report from MedMarket Diligence report #A125.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: ablation, rf ablation, microwave, ultrasound, HIFU, laser, cancer, oncology

Treatment alternatives for coronary artery disease run the gamut of techniques, technologies

reports@mediligence.com — Thu, 4 Jun 2009 12:12:50 -0700

Treating atherosclerotic disease in coronary arteries has for some years been the target of multiple different clinical procedures and medical technologies. While much caseload is apportioned to either coronary artery bypass grafting or percutaneous coronary (cath lab) interventions, the variety goes beyond these two simple choices.

The advanced medical technologies blog details the range of options in place and under continued development as the technologies evolve and caseload shifts toward those providing optimal performance.

See the May 2009 report #C245, "Worldwide Coronary Stents Market, 2008-2017." The report may be purchased for immediate download online or may be ordered via order form.

Tags: stents, drug eluting, drug-coated, angioplasty, PTCA

Growth in patient caseload for surgical securement products

patrick@mediligence.com — Sat, 30 May 2009 10:13:48 -0700

Caseload continues to grow for the use of the broad category of products called "surgical securement", encompassing advanced products in surgical sealants, glues, hemostasis, and other wound closure and anti-adhesion products, according to a 2009 report by MedMarket Diligence, LLC.

"Worldwide, over 100 million surgical and traumatic wound types and applications are potential candidates for use of these products, and the breadth of these applications illustrate the great clinical utility of these products," says Patrick Driscoll of MedMarket Diligence.  "These applications span cardiovascular, orthopedic and arthroscopic, digestive, urological, neurological, cosmetic, and general surgery, displacing many traditional wound closure  products."

The market for surgical closure and securement has entered a phase in which major driving forces are the introduction of new procedures and techniques by the surgical profession, the development by the medical device industry of new wound closure devices and biomaterials, and the growing willingness of surgical specialists to use these devices in appropriate circumstances. There is now a continuum between simple closure using sutures and the use of specially designed devices and delivery systems with new bioresorbable securement materials either as supplements to conventional closure methodology or as stand-alone replacements.

Among all potential clinical applications, surgical securement products play critical roles in reducing mortality and complications for roughly 26 million surgical procedures and, in another 50 million surgical procedures, securement products provide distinct improvements in clinical outcomes.  In another 40 million procedures, securement product reduce procedure time, provide cost savings or provide other benefits.

The MedMarket Diligence report #S175, "Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013," is a market and technology assessment and forecast of products in wound closure. The report details the current and emerging products, technologies and markets involved in wound closure and sealing using sutures and staples, tapes, hemostats, fibrin and sealant products, medical adhesives and products to prevent post-surgical adhesions. The report provides a worldwide current and annual forecast to 2013 of the markets for these technologies, with particular emphasis on the market impact of new technologies through the coming decade.  The report provides specific forecasts and shares of the worldwide market by segment for the U.S., Europe (United Kingdom, German, France, Italy, BeNeLux), Latin America, Japan and Rest of World.

The report provides background data on the surgical, disease and traumatic wound patient populations targeted by current technologies and those under development, and the current clinical practices in the management of these patients, including the dynamics among the various clinical specialties or subspecialties vying for patient population and facilitating or limiting the growth of technologies.

The report establishes the current worldwide market size for major technology segments as a baseline for and projecting growth in the market over a ten-year forecast. The report also assesses and projects the composition of the market as technologies gain or lose relative market performance over this period.

For more details on this report, including description, table of contents, list of exhibits and ordering information, see http://www.mediligence.com/rpt/rpt-s175.htm.

The report may be ordered online (for immediate download) from http://www.mediligence.com/store/page29.html or may be ordered via fax order form from http://www.mediligence.com/order_forms/s175_order.pdf.

About MedMarket Diligence
MedMarket Diligence provides tactical decision-making solutions on medical technology to the medical products and investment industries. The company publishes dedicated Reports on medical technology markets and offers the Medtech Startups Database on hundreds of newly founded medtech companies.

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MedMarket Diligence provides data and insight to the medical products, investment and other industries on advanced medical technologies through focused medical technology market and assessment Reports and the Medtech Startups Database.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: surgical sealant, surgical glue, fibrin sealant, fibrin glue, medical glue, medical adhesive, anti-adhesion

SYNTAX: Percutaneous Coronary Intervention (PCI) compared to Coronary Artery Bypass Grafting (CABG)

reports@mediligence.com — Sun, 24 May 2009 16:18:12 -0700

This is one of the largest clinical trials comparing PCI (with DES) with CABG. Results presented at TCT 2008 found no significant difference in treatment outcomes of patients who were stented compared with those who underwent coronary artery bypass grafting.

The advanced medical technologies blog reviews the SYNTAX trial (and notes the reviews of clinical trials detailed in the MedMarket Diligence Report #C245, "Worldwide Market for Drug-Eluting, Bare and Other Coronary Stents, 2008-2017." The report, described here, may be purchased online or via order form.

Tags: stents, drug eluting, drug-coated, angioplasty, PTCA

Advanced securement products versus conventional products in non-USA Americas

patrick@mediligence.com — Thu, 21 May 2009 13:57:02 -0700

Taken together, the Americas represent some 60% of the global market, led by the United States with more than 50%. The main medical markets in Latin America are Brazil and Mexico, followed by Argentina.

The advanced medical technologies blog, drawing on MedMarket Diligence report #S175 on the Worldwide Market for Surgical Sealants, Glues and Wound Closure," highlights the markets for advanced surgical securement products (sealants, glues, hemostats, anti-adhesion) in the non-USA markets of the Americas.

The wealthier, private-insurance-dominated healthcare market in the USA drives a heavier share of securement product sales in the advanced sector (sealants, glues, hemostats, anti-adhesion) compared to the large Latin American markets of Brazil, Argentina and Mexico, where conventional securement products (sutures, staples, tapes) predominate. However, growth remains strongest for advanced securement products -- in all geographic markets.

Securement products worldwide are described in the MedMarket Diligence report #S175.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: surgical sealant, surgical glue, fibrin sealant, fibrin glue, medical glue, medical adhesive, anti-adhesion

Dermal repair disorders, prevalence and applications for securement products

patrick@mediligence.com — Wed, 20 May 2009 21:10:42 -0700

Skin securement has always been an essential final step in surgical procedures. Historically, the skin surface was sutured; in recent years a number of advances have been made, including new tapes, sutures, staples, hemostats, and glues. High strength glues, in particular, find some of their biggest potential in dermal applications, given the problems of, for example, cyanoacrylate toxicity for internal applications.

The advanced medical technologies blog, drawing on MedMarket Diligence report #S175 on the Worldwide Market for Surgical Sealants, Glues and Wound Closure," illustrates the potential for surgical securement products for their application in treatment of venous ulcers, pressure ulcers, and burns, as well as for their significant volume of usage in plastic surgery.

Securement products worldwide are described in the MedMarket Diligence report #S175.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: surgical sealant, surgical glue, fibrin sealant, fibrin glue, medical glue, medical adhesive, anti-adhesion

Taking the lead in the coronary stent market: U.S.? Europe? China?

reports@mediligence.com — Tue, 19 May 2009 20:53:18 -0700

For many medical technology markets, the dynamics of technology development are usually such that innovation arises in western economies (especially U.S. and Europe) and migrates to Asia/Pacific and the rest of the world.

But the dynamic is different in the market for coronary stents. And it has much less to do with technology migration than market size.

The advanced medical technologies blog, drawing on the May 2009 report #C245, "Worldwide Coronary Stents Market, 2008-2017," explores the geographic impact of different coronary stent types.

Report #C245, "Worldwide Market for Drug-Eluting, Bare and Other Coronary Stents, 2008-2017." The report, described here, may be purchased for immediate download (and with limited time discount) online or may be ordered via order form.

Tags: stents, drug eluting, drug-coated, angioplasty, PTCA

Adoption of surgical securement products by clinical category and key determinants

patrick@mediligence.com — Tue, 19 May 2009 17:07:11 -0700

The potential for products in the surgical securement (sealants, glues, sutures/staples, hemostats, anti-adhesion) is driven by clinical category and the impact of the particular products, in each specialty, on a hierarchy of determinants, from the "important and enabling" to the "aesthetic and perceived benefits". This results in a variable distribution by clinical category (see blog entry for category definitions) in the potential of each.

The development, adoption, use and markets for securement products worldwide are described in the MedMarket Diligence report #S175.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: surgical sealant, surgical glue, fibrin sealant, fibrin glue, medical glue, medical adhesive, anti-adhesion

Despite multiple therapeutic alternatives, opportunities remain strong for coronary stent manufacturers

reports@mediligence.com — Fri, 15 May 2009 14:20:49 -0700

Because the ultimate therapy for the treatment of coronary artery disease has not yet been found, many opportunities still exist for effective therapies to combat atherosclerosis. So far, coronary stents hold the most promise for effectively treating an aging population with an increasing incidence of coronary artery disease.

The "advanced medical technologies" blog sources the MedMarket Diligence report #C245 on the worldwide coronary stents market in highlighting the opportunities for stents in the treatment of coronary artery disease -- despite multiple therapeutic alternatives.

Report #C245, "Worldwide Market for Drug-Eluting, Bare and Other Coronary Stents, 2008-2017." The report, described here, may be purchased for immediate download (and with limited time discount) online or may be ordered via order form.

Tags: stents, drug eluting, drug-coated, angioplasty, PTCA

Coronary Stents Market Worldwide Holds Big Incentive for Growth, Opportunity in Novel Technologies, According to New MedMarket Diligence Report

reports@mediligence.com — Mon, 4 May 2009 09:15:59 -0700

The market for coronary stents is, in many ways, still emerging. While coronary stents have been on the commercial market in one form or another for several years, the technologies and materials used to create the devices are improving every day. In addition, innovative technology is bringing new classes of devices (e.g., fully degradable stents) to market, technologies that grow the market and even expand stent therapy to new patient populations in some cases.

Report #C245, "Worldwide Market for Drug-Eluting, Bare and Other Coronary Stents, 2008-2017." The report, described here, may be purchased for immediate download (and with limited time discount) online or may be ordered via order form.

Tags: stents, drug eluting, drug-coated, angioplasty, PTCA

Worldwide Coronary Stents Market

pjd@mediligence.com — Tue, 21 Apr 2009 12:57:54 -0700

The global market for drug-eluting, bare and bioresorbable stents for the treatment of coronary artery disease is in a "growth and proliferation" phase, as the market for these devices is growing steadily through application to growing patient caseload, and as the number of companies with approved products or products in development multiplies.
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The advanced medical technologies blog highlights the three major sectors of coronary stents: drug-eluting, bare and bioresobable.

Report #C245, "Worldwide Market for Drug-Eluting, Bare and Other Coronary Stents, 2008-2017." The report, described here, may be advance purchased (with discount on paid orders) online or via order form.

Tags: stents, drug eluting, drug-coated, angioplasty, PTCA

New surgical techniques drive market opportunity in surgical sealants, glues market

patrick@mediligence.com — Wed, 15 Apr 2009 11:50:33 -0700

Changes in surgical practice, including the emergence of new surgical techniques, are creating and expanding the opportunities for surgical sealants, glues and wound closure.

The 2009 MedMarket Diligence report describes the expanding market opportunity for adjunctive surgical closure and securement products, gives an overview of the technical background for new products, describes existing competitors with products in relevant market segments, and offers five-year market growth estimates. The report covers sutures, staples, tapes, hemostats, surgical sealants, high-strength surgical glues, and adhesion prevention products.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: surgical sealant, surgical glue, fibrin sealant, fibrin glue, medical glue, medical adhesive, anti-adhesion

Worldwide Market for Drug-Eluting, Bare, Bioresorbable and Other Coronary Stents, 2008-2017. New MedMarket Diligence Report

pjd@mediligence.com — Wed, 8 Apr 2009 14:12:03 -0700

Any treatment for coronary artery disease will of necessity consider the competitive threat of bare versus drug-eluting stents, angioplasty, atherectomy (waning but not gone), products for identification/treatment of vulnerable plaque, traditional coronary artery bypass, MIDCAB, OPCAB and other bypass variants (e.g. robotics), percutaneous bypass, atherosclerosis-reversing drugs and others.

From the manufacturer’s side, it is a complex competitive landscape. For example, once was that any angioplasty manufacturer could reasonably consider his/her competitors to be all other manufacturers of devices that produce catheter-based recanalization of the atherosclerotic lumen. Those days are gone, for woe the angioplasty manufacturer now who does not also consider atherectomy, transmyocardial laser revascularization, bare metal stents, drug-eluting stents, traditional/open, MIDCAB (and similar) or and even percutaneous coronary artery bypass graft, let alone the classes of drugs and other non-device approaches to produce non-surgical reversal of atherosclerosis
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MedMarket Diligence, drawing on its coverage of coronary stents through the previously published MedMarkets publication and leveraging its expertise in assessing advanced medical technologies markets, is publishing its 2009 report, "Worldwide Market for Drug-Eluting, Bare, Bioresorbable and Other Coronary Stents, 2008-2017."

Report #C245, "Worldwide Market for Drug-Eluting, Bare and Other Coronary Stents, 2008-2017." The report, described here, may be advance purchased (with discount on paid orders) online or via order form.

Tags: stents, drug eluting, drug-coated, angioplasty, PTCA

Worldwide Surgical Sealants, Glues, Wound Closure, Anti-Adhesion Markets, 2009-2013. MedMarket Diligence Report

patrick@mediligence.com — Sun, 5 Apr 2009 18:22:35 -0700

The 2009 MedMarket Diligence report describes the expanding market opportunity for adjunctive surgical closure and securement products, gives an overview of the technical background for new products, describes existing competitors with products in relevant market segments, and offers five-year market growth estimates. The report covers sutures, staples, tapes, hemostats, surgical sealants, high-strength surgical glues, and adhesion prevention products.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: surgical sealant, surgical glue, fibrin sealant, fibrin glue, medical glue, medical adhesive, anti-adhesion

Ablation technologies in cardiology, oncology, general surgery, gynecology, elective surgery, and orthopedics. Worldwide market 2007-2017.

pjd@mediligence.com — Thu, 2 Apr 2009 14:38:52 -0700

Technologies for the therapeutic ablation of tissue include the use of radiofrequency, ultrasound, laser, microwave, thermal, hydromechanical, cryogenic, and electrical. These are routinely applied in cardiology, oncology, general surgery, gynecology, elective surgery, and orthopedics.

The MedMarket Diligence report #A125 details the worldwide market, to 2017 for each of these modalities, with segmentation by U.S., Canada, Brazil, Mexico, United Kingdom, Germany, Italy, France, Spain, BeNeLux, Japan, China, India, Australia and Rest of World.

The report is described in detail, with table of contents and list of exhibits, here. The report may be purchased via faxed order form or for immediate download online.

Tags: ablation, rf ablation, microwave, ultrasound, HIFU, laser

Worldwide Coronary Stent Market Growth, Market Opportunities; April 2009 MedMarket Diligence Report

pjd@mediligence.com — Thu, 2 Apr 2009 10:09:29 -0700

The worldwide market for coronary stents, including drug-eluting, bare metal, bioabsorbable others, is reflecting all of the dynamics one would expect: high growth based on clinical success in providing an alternative to surgical (e.g., bypass) intervention, a proliferation of competitors (over 75 active companies) seeking market share, a diversification of available and developing technologies and challenges to the top players, J&J and Boston Scientific, who once reaped the early rewards of a monopoly-like status. The worldwide coronary stent market is detailed in the April 2009 report (#C245) by MedMarket Diligence.

The report may be ordered with an advance purchase discount (order form or online).

Tags: stents, drug eluting, drug-coated, angioplasty, PTCA

Spine Fusion, Non-Fusion, Other Worldwide Spine Surgery Procedures, and Market Growth by Country (U.S., EU [Germany, UK, France, Italy]), Asia./Pacific, Rest of World

patrick@mediligence.com — Thu, 26 Mar 2009 08:31:44 -0700

Procedures and markets worldwide and by country are provided in the MedMarket Diligence Report #M510, "Spine Surgery: Products, Technologies, Markets & Opportunities, Worldwide, 2008-2017."

See the advanced medical technologies blog, which has numerous excerpts from the report, for a glimpse at this well-read industry report.

The MedMarket Diligence report on the "Worldwide Spine Surgery Market" is described here. and is available for purchase and immediate download here.

Tags: spine surgery, disc replacement, spine fusion, interbody fusion

Drug-Eluting Balloons as Alternative to Combined Angioplasty/Stenting (MedMarket Diligence)

pjd@mediligence.com — Thu, 19 Mar 2009 11:05:46 -0700

As the huge worldwide market for coronary stents -- whether drug-coated, bare metal, bioabsorbable or other -- continues to expand and draw an increasing number of competitors, a handful of innovators are pursuing an alternative idea: drug-eluting balloons. The "advanced medical technologies" blog has a recent review of drug-eluting balloons, drawn from the forthcoming (April) publication of the MedMarket Diligence Report #C245, "Worldwide Market for Drug-Eluting, Bare and Other Coronary Stents, 2008-2017."

Tags: stents, drug eluting, drug-coated, angioplasty, PTCA

Traditional Wound Closure (Sutures, Tapes, Staples) Undergoing Inexorable Shift Toward Use of Surgical Sealants and Glues, According to 2009 MedMarket Diligence Report

pjd@mediligence.com — Thu, 12 Mar 2009 14:37:24 -0700

The use of novel fibrin sealants, fibrin glues, medical adhesives and other products for wound closure has become nearly as routine as the use of traditional sutures, staples and tapes in wound closure. MedMarket Diligence's 2009 report on "Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013" details the global market for wound closure and related products. The report is described here.

The report may be purchased online for immediate download.

Tags: medtech, surgical sealants, fibrin sealants, surgical glues, cyanoacrylates

Products, technologies, companies and worldwide markets in hemostasis

pjd@mediligence.com — Sun, 8 Mar 2009 13:26:11 -0700

Distribution of wound closure, sealants, and other securement product sales in the Americas

pjd@mediligence.com — Fri, 6 Mar 2009 11:36:07 -0800

The distribution of wound closure products varies in the Americas. With varying degrees, surgical sealants are steadily penetrating wound closure markets that are, for the time being, still represented in the marjority by traditional sutures and staples.

The advanced medical technologies blog posts the distribution of wound closure products in the U.S., Brazil, Mexico, Argentina and other Latin American countries.

Drawn from Report #S175 by MedMarket Diligence.

Obesity costs rising, but spending on treatment has big positive impact on indirect costs

pjd@mediligence.com — Thu, 5 Mar 2009 13:25:26 -0800

Among all costs that are contributing to healthcare being expensive in the U.S., those associated with obesity must be near the top of the list. The advanced medical technologies blog highlights both why it is important for the U.S. to recognize this, but understand too that money spent on obesity treatment is well spent.

MedMarket Diligence's report on the "Worldwide Market for the Clinical Management of Obesity" is described, with full table of contents and list of exhibits, here.

The report can also be ordered online here.

Tags: obesity, bariatric,

Medical technology opportunities driven by demand, enabling technologies and even economics

pjd@mediligence.com — Thu, 26 Feb 2009 07:38:35 -0800

Despite economic challenges (and in some cases because of them), opportunities are numerous in the medical technology arena. Enabling technologies and the persistent nature of demand for products in healthcare give rise to promising new products penetrating existing markets or even creating new ones.

A White Paper from MedMarket Diligence on high growth medical technologies details the technologies and opportunities. See link to register for free access.

New surgical techniques drive market opportunity in surgical sealants, glues market

pjd@mediligence.com — Sat, 21 Feb 2009 09:24:40 -0800

The active manufacturers in the market for sealants & glues technologies used in traumatic, surgical and other wound closure, (tapes, sutures and staples) as well as hemostats and anti-adhesion products are profiled in the December 2008 MedMarket Diligence report #S175, "Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013." The report is described here.

The report may be purchased online for immediate download.

Tags: medtech, surgical sealants, fibrin sealants, surgical glues, cyanoacrylates

Medical technology platforms with high growth potential

pjd@mediligence.com — Wed, 18 Feb 2009 21:50:39 -0800

Review of top new medical technologies and/or platforms. Subject of MedMarket Diligence White Paper discussed in recent "advanced medical technologies" blog. Technologies include biotech alternatives to medical devices, drug-device hybrids, RFID, ablation, tissue engineering, bioresorbables, and others.

For a complete listing of MedMarket Diligence reports, see link. See also the Medtech Startups Database.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

New surgical techniques drive market opportunity in surgical sealants, glues market

pjd@mediligence.com — Wed, 18 Feb 2009 19:14:37 -0800

Growth in surgical techniques, many new, are increasing the size of the opportunity for surgical sealants, glues, hemostasis and other products. With surgeon experience growing in the new techniques, many of which are less invasive, the potential patient population for the procedures is increasing (e.g., spine surgery) as surgery is more completely penetrating the potential surgical caseload. The aging demographic simply adds to the momentum in this trend.

The "Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013," is detailed in a new report from MedMarket Diligence. The report is described here.

Tags: medtech, surgical sealants, fibrin sealants, surgical glues, cyanoacrylates

Trends and Opportunities in the Rapidly Growing Worldwide Ablation Technologies Market;

patrick@mediligence.com — Tue, 17 Feb 2009 09:35:03 -0800

The global market for medical devices is currently a $185 billion opportunity and at least 13% of this market involves products that provide the controlled application of energy to tissue. The segment is dominated by high technology products ranging from devices that can heat and cool tissue over a 600° C temperature range of -200° C to +400° C to those that can vibrate at fifty five thousand cycles per second to denature tissue. While a significant share of the energy-based therapies market is for elective procedures such as refractive eye surgery and cosmetic hair removal, treatments for chronic diseases make up the vast majority of the applications of these technologies.

Underlying the growth of this market will be changes in demographics. The baby boomer generation--those born between 1946 and 1964--represents about one-third of the population in economically-developed countries. Many of these ageing citizens have both the economic means and the demand for therapies that can extend their active lives and delay the visible signs of aging.

Pushing the growth of energy therapies beyond basic changes in demographics are the unique benefits that they offer. They are typically less invasive than traditional surgery and are generally employed without the need for an implant. The therapies can be precisely metered and can be repeated. Emerging energy modalities have the potential to grow at significant, double-digit rates over the next decade as delivery systems evolve.

The MedMarket Diligence report on the "Worldwide Ablation Technologies Market, 2008-2017" is described here. and is available for purchase and immediate download here.

Degenerative disc diseases, implications for spinal surgery technologies

patrick@mediligence.com — Mon, 16 Feb 2009 16:51:22 -0800

Degenerative disc disease are a major impetus for spine surgery. The advanced medical technologies blog, in an excerpt from the MedMarket Diligence report on Spine Surgery, reviews the clinical background for these conditions.

Product development timeline, clinical trends in hemostasis, medical/surgical sealants and glues, wound closure

pjd@mediligence.com — Tue, 3 Feb 2009 09:35:44 -0800

During the 19th century, surgeons began to experiment with materials designed to achieve hemostasis: gelatin, collagen, natural fabrics, and thrombin and fibrin materials. In the early 1980s today’s commercial products began to appear. They were rapidly adopted in Japan where bleeding is an extremely emotive issue, and also in Europe where local regulatory requirements allowed a sequential roll-out of product introductions. In the United States, early FDA concerns associated with disease transmission led to delayed launch of products derived from human sources. These regulatory delays, plus the perceived high cost of products and surgeons’ concerns regarding disease transmission risk, drove surgeons and hospitals to continue to look for alternative hemostats, sealants and glues. As a result, to this day there is a tendency for hospitals to continue to prepare autologous fibrin (from the patient’s own blood taken before surgery) and to use a number of inferior hemostasis products.

Topical high-strength glues were first used by the military and to achieve immediate repair of sports injuries during professional sports like ice hockey, boxing and American football and basketball. These products became the subject of collaborative efforts between innovative suppliers and major suture manufacturing and marketing companies, keen to evolve their product portfolios to include next-generation closure materials.

During the 1990s, many technology-based companies began to target the huge unmet closure and sealant market and extensive literature appeared, advising practitioners on specific methodology to create the ideal autologous fibrin sealant product and on applying these products to surgical indications. In addition, a number of specialist societies were established to support and advise on the process of preparing and using hospital-derived fibrin sealants.

There were also a growing number of companies developing medical devices and equipment specifically designed to allow the preparation of autologous fibrin sealant for surgical applications. All this effort led to a number of products being approved for use in the major surgical indications (see Exhibit 1-7, report #S175). In 2006, sealant products were used in over three million surgical procedures. This represents up to 5 million units of commercially available fibrin sealant products, and approximately four million units of autologous fibrin prepared by hospitals. The autologous fibrin material, prepared using commercial medical devices, was used in approximately 70,000 surgical operations worldwide and represents a new market that has developed over the last five years. Similarly, the use of high-strength glues for wound closure evolved since 1992 in Europe and since 1998 in the United States and Japan. High-strength adhesives were used on approximately 6 million cuts, grazes and minor incisions in 2006. This usage is growing rapidly driven by greater awareness and cost-effectiveness.

The above is an excerpt from "Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013," the December 2008 report from MedMarket Diligence. The report is described in detail here.

Tags: medtech, hemostasis, surgical sealants, fibrin sealants, surgical glues, cyanoacrylates

Growing Caseload, Range of Applications, Participating Companies and Worldwide Markets in Surgical Sealants, Glues, Hemostasis and Anti-Adhesion, According to MedMarket Diligence Report

pjd@mediligence.com — Wed, 28 Jan 2009 07:52:34 -0800

The steady rate of adoption by physicians using novel wound closure, hemostasis and anti-adhesion products, the growing caseload to which products are being applied, the proliferation of companies developing and introducing products and the expanding international markets for them are collectively responsible for the high growth in the market for these products.

The "Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013," is detailed in a new report from MedMarket Diligence. The report is described here.

Tags: medtech, surgical sealants, fibrin sealants, surgical glues, cyanoacrylates

Hemostasis in wound management

pjd@mediligence.com — Thu, 22 Jan 2009 07:42:55 -0800

Hemostat: A hemostat reacts in the presence of blood to establish the normal cascade of factors that arrest bleeding. These products can be added to a bleeding field during surgery to prevent further bleeding, and are mostly dependent on a full complement of normal factors in the patient’s blood.

Hemostats have been used for over a hundred years to prevent bleeding in the surgical situation. Primarily these products were first introduced to prevent hematomas during surgery with the aim of preventing resultant infections. During the 1980s and 1990s, the popularity of hemostats increased rapidly as surgeons tried to avoid excessive use of blood transfusions for reasons of economy and the threat of disease transmission. Products were launched during this period by many of the large medical device manufacturers, such as Johnson & Johnson, which now sells Surgicel (an oxidized regenerated cellulose hemostat), Instat (a freeze-dried collagen product), Spongostan (a freeze-dried gelatin hemostat), and Thrombocoll (a freeze-dried thrombin powder). A myriad of products continue to be introduced to the market for hemostasis, targeting improved performance in a wider array of clinical applications.

As part of the detailed worldwide analysis of surgical sealants, glues and other wound closure and anti-adhesion products market, MedMarket Diligence assesses the products, technologies, competitors and worldwide markets for hemostasis.

Tags: medtech, hemostasis,surgical sealants, fibrin sealants, surgical glues, cyanoacrylates

Surgical closure and securement products defined

pjd@mediligence.com — Tue, 20 Jan 2009 13:15:44 -0800

The market for securement products may be subdivided into the following product categories: sutures, staples and other mechanical closure devices; tapes; hemostats; fibrin and other sealants; high-strength medical adhesives; and post-surgical adhesion prevention. These are further defined in the advanced medical technologies blog.

MedMarket Diligence tracks wound closure, hemostasis and anti-adhesion technologies and forecasts this market in a forthcoming worldwide report, with insight into market introduction, growth, competition and business opportunity. The 2009 report details the markets worldwide, with detailed geographic segmentation, for surgical sealants, glues, hemostats, sutures, tapes, other wound closure technologies and products in the prevention of post-surgical adhesion.

The report is entitled, "Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013."

The report is detailed here and may be ordered by order form or via online order for immediate download.

Tags: medtech, surgical sealants, fibrin sealants, surgical glues, cyanoacrylates

Dermal applications, prevalence for use of surgical sealants, glues, securement

pjd@mediligence.com — Tue, 13 Jan 2009 06:01:32 -0800

The blog on advanced medical technologies excerpts coverage of the dermal (skin repair) applications of surgical sealants and glues. These applications are prevalent and readily amenable to sealants and glues.

New Published Report from MedMarket Diligence: Surgical Sealants, Glues, Hemostasis and Wound Closure Market, 2009-2013

pjd@mediligence.com — Thu, 8 Jan 2009 10:43:27 -0800

Opportunities for products in wound closure, hemostasis and anti-adhesion products are plentiful for established and emerging companies, driven by innovation in product formulation and penetration of more caseload, including growth in more medical and surgical specialties. The market for these products is also growing through their expansion globally, with products being introduced and finding clinical acceptance in the U.S., Europe, Central and South America and other markets globally.

MedMarket Diligence tracks wound closure, hemostasis and anti-adhesion technologies and forecasts this market in a forthcoming worldwide report, with insight into market introduction, growth, competition and business opportunity. The 2009 report details the markets worldwide, with detailed geographic segmentation, for surgical sealants, glues, hemostats, sutures, tapes, other wound closure technologies and products in the prevention of post-surgical adhesion.

The report is entitled, "Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013."

The report is detailed here and may be ordered by order form or via online order for immediate download.

Tags: medtech, surgical sealants, fibrin sealants, surgical glues, cyanoacrylates

High growth geographic markets in ablation technologies

patrick@mediligence.com — Mon, 8 Dec 2008 17:37:37 -0800

Review of "Worldwide Ablation Technologies Markets", Report #A125 from MedMarket Diligence reveal where the high growth geographic markets are for ablation technologies.

For a complete listing of MedMarket Diligence reports, see link.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: medtech, ablation, cryoablation, microwave, rf ablation

Top New Medical Technologies and/or Platforms

patrick@mediligence.com — Sun, 23 Nov 2008 19:40:31 -0800

Review of top new medical technologies and/or platforms. Subject of MedMarket Diligence White Paper discussed in recent "advanced medical technologies" blog. Technologies include drug-device hybrids, RFID, ablation, tissue engineering, bioresorbables, and others.

For a complete listing of MedMarket Diligence reports, see link. See also the Medtech Startups Database.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: medtech, innovation, biotech

Companies in Surgical Sealants, Glues, Wound Closure, Anti-Adhesion, Worldwide; New 2009 MedMarket Diligence Report

patrick@mediligence.com — Thu, 20 Nov 2008 11:00:26 -0800

The number of companies active in marketing and/or developing products in surgical sealants, glues, wound closure and anti-adhesion is testimony to the opportunity in this growth arena.

Below is a selection of companies profiled in the December 2008 report:

3DM, Inc. (3D-Matrix, Ltd.), Abbott Vascular, AccessClosure, Inc., Adhezion Biomedical, LLC , Advanced Medical Solutions , Angiotech Pharmaceuticals, Inc., Anika Therapeutics, Inc., ARC Pharmaceuticals Inc., Arch Therapeutics (formerly Clear Nano Solutions), ArthroCare Corporation, B. Braun Melsungen AG, Bard Medical Division, CR Bard, Baxter International Inc., Bayer Schering Pharma, BD (Becton Dickinson and Company), Biiosyntech Inc., Biocoral Inc, Biogentis, Inc., BIOSTER a.s., Cardiovascular Sciences, Inc., Cardiva Medical, Inc., Ceremed, Inc., Chemence Ltd., Cohera Medical, Inc., Collagen Matrix, Inc., Covidien, CryoLife, Inc., CSIRO PhotoMedical Technologies, CSL Behring, CSMG, Inc., CuraMedical BV, DePuy, Inc., Entegrion, Ethicon, Inc., Johnson & Johnson, FibroGen, Inc., Fidia Advanced Biopolymers SpA, Flamel Technologies SA, Focal, Inc., Forticell Bioscience, FzioMed, Inc., GEM s.r.l., Genzyme Biosurgery, GluStitch, Inc., Haemacure Corporation, Harvest Technologies Corporation, HemCon, Inc., Hemostasis LLC, Henkel Loctite Corp., HyperBranch Medical Technology, Inc., Innovasa Corporation, Integra Lifesciences Corporation, Interpore Cross International, Isto Technologies, Inc., I-Therapeutix, Inc., Kaketsuken (Chemo-Sero-Therapeutic Research Institute), Kensey Nash Corporation, Kimberly-Clark Health Care, King Pharmaceuticals, Inc., LifeBond, Ltd., Lifecore Biomedical Inc., Marine Polymer Technologies, Medafor, Inc., MedTrade Products, Meyer-Haake GmbH Medical Innovations, Morris Innovative, Neose Technologies, Nycomed Pharma AS, Omrix Biopharmaceuticals Inc., Organogenesis, Inc., Pharming Group NV, Plasma Technologies, Inc., PlasmaSeal LLC, Pluromed, Inc., Polyganics, BV, ProFibrix BV, Protein Polymer Technologies, Inc., Radi Medical Systems AB, Scion Cardio-Vascular, Inc., Sea Run Holdings, Smith & Nephew Plc , Sutura Inc., Synovis Life Technologies, Inc., Teleflex Medical, ThermoGenesis Corp., Therus Corporation, Thrombotargets Corp., Tissuemed Ltd., TraumaCure, Inc., TyRx Pharma, Inc. , Vascular Solutions, Inc. , Vectura Group plc , Vivostat A/S, Z-Medica Corp. The MedMarket Diligence report #S175, "Worldwide Surgical Sealants, Glues and Wound Closure Market, 2009-2013," is described at this link including details on the advanced purchase discount.

For a complete listing of MedMarket Diligence reports, see link. See also the Medtech Startups Database.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: surgical sealant, surgical glue, fibrin sealant, fibrin glue, medical glue, medical adhesive, anti-adhesion

Surgical Sealants, Glues, Wound Closure, Anti-Adhesion, Worldwide; New 2009 MedMarket Diligence Report

patrick@mediligence.com — Thu, 20 Nov 2008 10:48:22 -0800

MedMarket Diligence's forthcoming (December 2008) report on surgical sealants, glues, wound closure and anti-adhesion details a dynamic market for products worldwide that are progressively becoming a mainstay of surgical and medical care across a wide range of clinical specialties.

"Worldwide Surgical Sealants, Glues and Wound Closure Market, 2009-2013." See link for details and advanced purchase discount.

For a complete listing of MedMarket Diligence reports, see link. See also the Medtech Startups Database.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: surgical sealant, surgical glue, fibrin sealant, fibrin glue, medical glue, medical adhesive, anti-adhesion

Reports on advanced medical technologies: sealants/wound closure, ablation technologies, spine surgery, wound management, others

patrick@mediligence.com — Fri, 14 Nov 2008 11:45:09 -0800

A range of new medical technology market analyses are available, with another pending, from MedMarket Diligence. These worldwide reports detail advanced medical technologies with worldwide scope on the products, technologies, markets and opportunities.

"Worldwide Surgical Sealants, Glues and Wound Closure Market, 2009-2013." See link for details and advanced purchase discount.

"Ablation Technologies Worldwide Market, 2008-2017: Products, Technologies Markets, Companies and Opportunities." See link for details.

"Spine Surgery Worldwide 2008-2017, 2007-2016: Products, Technologies, Markets and Opportunities." See link for
details.

"Worldwide Wound Management, 2007-2016: Established and Emerging Products, Technologies and markets in the U.S., Europe, Japan and Rest of World." See link for details.

"Worldwide Market for the Clinical Management of Obesity, 2007-2015." See link for details.

For a complete listing of MedMarket Diligence reports, see link. See also the Medtech Startups Database.

For additional information, contact Patrick Driscoll, patrick at mediligence dot com, tel: 949-859-3401.

Tags: ablation, rf ablation, microwave, ultrasound, HIFU, laser

Ablation: Radiofrequency Among Big Growth Segments in Surgery

patrick@mediligence.com — Tue, 11 Nov 2008 16:07:26 -0800

The surgical ablation of soft tissues will see significant growth in the next few years and, among the different modalities employed, radiofrequency will demonstrate some of the most significant growth.

Growth among the ablation technology segments and a focus on radiofrequency are highlights of a recent "advanced medical technologies blog.

Ablation Technologies are the focus of a global report from MedMarket Diligence. Report #A125, entitled, "Ablation Technologies Worldwide Market, 2008-2017: Products, Technologies Markets, Companies and Opportunities," is described at this link and is available for purchase and immediate download online.

Tags: ablation, rf ablation, microwave, ultrasound, HIFU, laser

Medical technology opportunities are many

patrick@mediligence.com — Fri, 7 Nov 2008 08:47:40 -0800

The downturn in the world economy, stemming as it does from overextended credit, including but not limited to bad lending in sub-prime mortgages, has no direct relevance for medical technology markets, which have numerous high growth segments. These offer very attractive opportunities for the medtech industry.

Segments with high growth are replete in ablation technologies, wound management, obesity management, spine surgery and others.

High growth segments are reviewed in the recent advanced medical technologies blog.

Tags: obesity, wound management, ablation, spine surgery

New medical technologies

patrick@mediligence.com — Tue, 28 Oct 2008 21:34:01 -0700

Selected companies are identified and their product/technology descriptions provided, from the Medtech Startups Database from MedMarket Diligence.

The Medtech Startups Database is described here. Technologies at startups are described, for recent months, here. To subscribe to the Medtech Startups Database, please do so online.

Recent and forthcoming reports from MedMarket Diligence:

Coming in December: Report #S175, "Worldwide Surgical Sealants, Glues and Wound Closure, 2009-2013."

Report #A125, "Ablation Technologies Worldwide: Products, Technologies, Markets, Companies and Opportunities."

Report #M510, "Spine Surgery Worldwide, 2008-2017: Products, Technologies, Markets and Opportunities."

Tags: startup,sealant, cyanoacrylate, fibrin, suture, hemostat, anti-adhesion, ablation, spine

Anti-adhesion, fibrin sealant, or both?

patrick@mediligence.com — Tue, 28 Oct 2008 06:47:33 -0700

Recent (fall 2008) clinical data is supporting the unusual premise that fibrin sealants, used for the sealing, closure and hemostasis of wounds, may also, when used appropriately, reduce the incidence, extent and severity of post-surgical adhesions. Clinical data from Haemacure's fibrin sealant, and similar investigative work by Angiotech on its CoSeal product, have opened up considerable new potential for these products in the large and largely unfulfilled market for anti-adhesion.

Sealants and securement products (encompassing sutures and staples, tapes, haemostats, sealants, high strength glues, and adhesion prevention products) offer distinct clinical and economic benefits. The clinical efficacy and cost benefits of using sealant and securement products are reviewed in the "advanced medical technologies" blog. This is also covered in Report #S175, "Worldwide Surgical Sealants, Glues and Wound Closure, 2009-2013."

Tags: sealant, cyanoacrylate, fibrin, suture, hemostat, anti-adhesion

U.S. Will Continue to Lead the Worldwide Bariatric Device Market

patrick@mediligence.com — Tue, 21 Oct 2008 10:11:08 -0700

The US and Canadian market for bariatric devices is growing at stunning rate, driven by an increasingly prevalent patient population, the increasing capability of physicians to perform bariatric procedures and a recognition by healthcare systems and third party payers to address the problem as a lynchpin for a condition that otherwise will drive up other, related healthcare costs. See blog and MedMarket Diligence Report #S825 on Obesity.

Tags: obesity, bariatric

In Asia/Pacific, China Dominates Conversation While Japan Dominates Markets

patrick@mediligence.com — Thu, 16 Oct 2008 22:04:28 -0700

Looking beyond the U.S. borders as well as the increasingly strong European Union, the conversation about large, growing markets frequently turns to the Asia/Pacific in general and to China in particular. But, according to a report from MedMarket Diligence, the market with greater growth and near term potential is instead Japan. See the attached forecast of the shares of the Asia/Pacific market for ablation technologies by China, Japan, India and Australia.

The worldwide market for ablation and other energy-based technologies is detailed in the new market and technology report, "Ablation Technologies Worldwide Market, 2008-2017: Products, Technologies Markets, Companies and Opportunities", from MedMarket Diligence, LLC

The report is described detail, with table of contents and list of exhibits, here.

Companies Developing and Marketing Ablation Technologies

patrick@mediligence.com — Thu, 16 Oct 2008 17:32:48 -0700

Given the breadth and depth of applications in ablation technologies, which encompass cardiology, oncology, general surgery, gynecology, orthopedics and other clinical areas, and which include technologies as diverse as microwave, cryotherapy, radiofrequency, laser, ultrasound, thermal, hydromechanical, and electrical, it is no surprise that a large and diverse group of companies are active in the market.

Below is a selection of companies covered in the MedMarket Diligence Report #A125, "Ablation Technologies Worldwide Market, 2008-2017: Products, Technologies Markets, Companies and Opportunities." (Published September 2008)

Abla-Tx Inc., Accuray, Accuray Inc., ACMI/Gyrus/Olympus, Acoustic MedSystems, AFx (Guidant), Alcon, Alcon Laboratories, Inc., American Medical Systems, Inc., AngioDynamics, Inc., ArthroCare Corporation, ATI Medical, Inc., AtriCure, Inc., ATS Medical, Bard Electrophysiology, Bard EP, Bausch & Lomb, Bausch & Lomb (Warburg Pincus), Baylis Medical Company Inc., Biomet, Inc., Biosense Webster, Inc., BIOTRONIK GmbH & Co. KG, Biowave Corporation, Boston Scientific Corporation, C. R. Bard, Inc., Candela Corporation, Cardima, Inc., Cardiogenesis Corporation, Celon AG medical instruments, Celsion Corporation, ConMed Corporation, Covidien Ltd., CryoCath Technologies Inc., CryoCor, Inc., CSA Medical, Inc., Cytyc Corporation, Dornier MedTech, EDAP TMS S.A., Edwards Lifesciences Corp., Elekta AB, Endocare, Inc., ERBE Elektromedizin GmbH, Erbe USA, Inc., Ethicon Endo-Surgery, Inc., Galil Medical Inc., Getinge AB, Guidant Corporation, Gynecare, Gyrus ACMI, Inc., HealthTronics, Inc., Integra Radionics, Inc., Light Sciences Corporation, Lumenis Inc., Maquet GmbH & Co. KG, Medtronic, Medtronic, Inc, MedWaves, Inc., Mirabilis Medica, Misonix, Inc., Mitek Products, NeuWave Medical Inc., Olympus Medical, Olympus Optical Company Ltd., OmniSonics Medical Technologies, Inc., Oncura, PhotoMedex, Inc., PhotoThera, Inc., PhotoTherapeutics Inc., ProSurg, Inc., Proxima Therapeutics, Inc., Radionics, RFA Medical, Inc., Sanarus Medical, Inc., SenoRx, Inc., Siemens Medical Solutions USA, Inc., Smith & Nephew plc, Spectranetics, St. Jude Medical, Inc., Starion Instruments Corporation, Stereotaxis, Inc., Stryker Instruments, Theragenics Corporation, TissueLink Medical, Inc., Urologix, Inc., USHIFU, Valleylab, Varian Medical Systems, Inc., VISX, Vivant Medical, VNUS Medical Technologies, Inc.

The complete report on the Worldwide Ablation Technologies Market is described, with complete table of contents and list of exhibits, here.

Tags: ablation, rf ablation, microwave, ultrasound, HIFU, laser

Spine Surgery Companies Take Advantage of Report Opportunity

patrick@mediligence.com — Wed, 15 Oct 2008 16:50:13 -0700

MedMarket Diligence has completed a worldwide analysis of spine surgery. Any company among the following who contacts us by email (reports(at)mediligence(dot)com) from a company email address will receive a reply back from us with an attractive offer to receive the Report #M510, "Spine Surgery: Products, Technologies, Markets & Opportunities Worldwide, 2008-2017."

Abbott Spine, AlloSource, Alphatec Holdings, Inc., Altiva Corporation, Anulex Technologies, Inc., ApaTech, Applied Spine Technologies, A-Spine Holding Group Corporation, Axial Biotech, AxioMed Spine Corporation, B. Braun/Aesculap, Inc., BioAssets Development Corporation, Biomet, Biorthex, Inc., Blackstone Medical, Inc, BrainLAB, Cardinal Health, Cervitech, Changzhou Kanghui, Co.Don AG, CoLigne AG, Cook Group, CoreSpine Technologies LLC, Corin Group, Cortek, Inc, Cryolife, Inc., Cyberkinetics Neurotechnology Systems, DePuy Spine/J&J, Disc Dynamics, Disc Motion Technologies, Encore Medical Corporation, Facet Solutions, Fixano, GE Healthcare, Gentis, Inc, Globus Medical, GMReis, HydroCision, Innovative Spinal Technologies, Integra LifeSciences, Integra Radionics, Interpore Cross, Interventional Spine, Invibio, LDR Holding Corporation, LifeNet Health, Inc., MacroPore Biosurgery Inc, Mazor Surgical Technologies Ltd, Medtronic, Inc, Medtronic Sofamor Danek, Medtronic Surgical Navigation, Mekanika, Inc., Merck & Co., Inc., MiMedx, Misonix, MTF (Musculoskeletal Transplant Foundation), NPS Pharmaceuticals, N Spine, Inc., NuVasive, Inc., Ortho Development Corporation, Orthofix International, N.V., OrthoVita, Osiris Therapeutics, Osteotech, Inc., Ortosintese, Paradigm Spine, LLC, Pitkar, Praxim, Ranier Technology Limited, Raymedica, Inc., Regeneration Technologies, Inc, Scient’X, SeaSpine, Inc., Sharma Surgical, Small Bone Innovations, LLC, Smart Disc, Smith & Nephew, SpinalMotion, SpineMedica Corporation, Spineology, SpineOvations, SpineVision Inc, Spine Wave, Inc., Stryker Corporation, Stryker Instruments, Stryker Spine, Synthes Spine Solutions, Theken Spine, TranS1, Inc., Trimedyne, Inc., Ulrich Medical GmbH, Valleylab, Vertebron Inc., Waston Medical, Wright Medical Technology, X-spine Systems, Inc., Zimmer Spine