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New technologies at medtech startups
(From the Medtech Startups Database)

2014

November

  • Handheld ultrasound, MRI imaging device.
  • Needle-free injection drug delivery.
  • Lenses designed to correct imbalance between eyes and brain that cause certain migraines.
  • Continuous blood glucose monitoring in diabetes.
  • Customized prosthetic aortic valve.
  • Cystoscope-implanted, stent-like device to treat urinary obstruction associated with benign prostatic hypertrophy.
  • Endovascular treatment for abdominal aortic aneurysm.
  • Respiratory therapy device based on "high frequency chest wall oscillation" for treatment of COPD, other respiratory disorders.
  • Treatment of arrhythmia.
  • Medical device commercialization company active in cardiovascular care, tissue ablation, medical infusions, hand surgery and laparoscopic surgery.
  • Surgical visualization systems.
  • Arthroscopic bone tunneler and other orthopedic surgical instrumentation.
  • Brain stimulation to treat multiple disorders.

October

  • Prosthetic disc nucleus in spine surgery.
  • Device and non-device technologies based on dynamics of blood flow.
  • Magnetic and fluorescent technology point-of-care device to detect heart attack.
  • Technologies for tissue reconstruction.
  • Adult stem cell therapy in orthopedics, aesthetics, and chronic diseases (diabetes, COPD, heart disease, multiple sclerosis, stroke/cerebrovascular disease).
  • Vagus nerve stimulation for neuromodulation treatment of various inflammatory autoimmune diseases.
  • Surgical devices including for endoscopic access closure.
  • Device to measure sympathetic nerve activity and produce ECG.
  • Simultaneously track electrical measures that indicate brain, heart, optical and musculoskeletal activity.
  • Needle-free pediatric withdrawal of blood.
  • Ventilation systems for improved delivery of gas, moisture and nebulized medication.
  • Broadly focused medical technology company active in osteoarthritis, cardiovascular, stroke, diabetes, infection control and spine surgery.

September

  • Robotics for ophthalmic surgery.
  • Dynamic force generation for bone repair.
  • Neursurgical brain simulation system.
  • Orthopedic technologies including pedicle screw that does not require a guide wire.
  • Synthetic bone graft materials.
  • Minimally invasive mitral valve replacement.

August

  • Technology for the repair of rotator cuff tears.
  • Technologies for intravenous cannulation and phlebotomy, and an otorhinoscope.
  • Implant for the treatment of urinary incontinence.
  • LED (light) treatment of acute, dry macular degeneration.
  • Esophageal cooling device to manage patient temperature.
  • Surgical robotics.
  • Patient positioning system for orthopedic surgery.
  • Device to treat macular degeneration by delivering microcurrent to the eye.

July

  • Instrumentation for electrophysiology diagnosis and treatment.
  • Products for the treatment of hypertension and other chronic disease. The initial product is aimed for the use of interventional cardiologists under fluoroscopy.
  • Surgical stapling device for use during natural orifice transluminal endoscopic surgery.
  • Low cost medical technologies to improve patient management in emerging markets.
  • Heart valve for the treatment of mitral valve regurgitation
  • Thrombectomy catheter
  • Microstaple bandage for wound closure.
  • Whole-body cryotherapy chambers as well as devices for local cryotherapy and cryosurgery.
  • Minimally invasive surgical device for the treatment of glaucoma
  • Electrical muscle stimulation.
  • Percutaneous transluminal angioplasty (PTA) catheter with infusion capability.
  • Imaged-guided, minimally invasive surgical tool for mitral valve repair.
  • Cryosurgical device
  • Therapeutic hypothermia to the spinal canal.

June

  • Intraocular lens for presbyopia.
  • Portable, wireless EKG device.
  • Tissue engineering in peripheral and central nervous system injury.
  • Micro transtympanic drug delivery to the ear.
  • Diagnosis of functional GI disorders.
  • Spinal implants and instrumentation systems.
  • Surgical suction devices.
  • Calcium phosphate bioceramic implants for bone defects.
  • Intervertebral fusion cage.
  • Monitoring of neural activity during sedation.
  • Surgical instrument positioning systems for minimally invasive and robotic surgery.
  • Critical care monitoring technologies.

May

  • Patient positioning system for use in hip replacement and other orthopedic procedures.
  • Instrumentation to facilitate hip replacement surgery and other orthopedic instrumentation.
  • Drug-coated stent-valve designed to inhibit stenosis, obstruction or calcification of the valve.
  • Implants for the treatment of aneurysm.
  • Orthopedic implant technologies including a force sensor to measure performance of an orthopedic articular joint.
  • Insulin patch pump for treatment of insulin-dependent type 2 diabetes.
  • Undisclosed tissue vascular technology
  • Rapid, accurate, inexpensive diagnostic devices initially focused on malaria.
  • Device for diagnosis and management of diabetic retinopathy.
  • Tumor-targeted drug delivery.
  • Near infrared technology for blood glucose monitoring in diabetes.
  • Non-resorbable films for anti-adhesion.
  • Angioplasty double balloon for treatment of peripheral vascular disease.
  • Device to reduce the risk of ventilator-associated pneumonia.
  • Trocar, sleeve and tip for minimally invasive endoscopic surgery.

April

  • Wireless maternal-fetal monitor
  • Raman spectroscopy for intraoperative endoscopic diagnosis of cancer.
  • Insulin delivery alternative to pens and syringes.
  • Radiofrequency ablation probe for the treatment of breast cancer.
  • Laparoscopic instruments designed to make surgeries less invasive and produce no scarring.
  • Devices for cardiac and vascular procedures designed for easier use and lower cost.
  • Knotless suture technology
  • Carbon nanotube fiber material to treat ventricular arrhythmia.
  • Tactile stimulator to work with fMRI, a dermatome for skin grafts and other technologies.

March

  • Cardiac assist device for patients otherwise needing transplant.
  • Custom surgical implants including using 3D printing.
  • Targeted, localized drug delivery.
  • Hemostatic dressing for non-compressible hemorrhage.
  • High resolution imaging in cancer
  • Image-guided surgery
  • Autologous cell therapy delivered at the intraoperative point of care.
  • Device to harvest bone grafts
  • Device and method for self-collection of samples to screen for HPV, chlamydia, and gonorrhea.
  • Implantable neuromodulation device for the treatment of chronic pain and overactive bladder
  • Encapsulated pancreatic cells for treatment of type 1 diabetes.
  • Embolization device.
  • Deep brain stimulation for Alzheimer's and other cognitive disorders.
  • Magnetoencephalography (MEG) and magnetocardiography (MCG).
  • Technologies to manage core temperature in critical care and post-surgical patients
  • New method to use pulse wave velocity to measure arterial stiffness as indicator of heart attack risk.
  • Minimally invasive hip implants and other orthopedic implants.
  • Orthopaedic implants.

February/January

  • Ophthalmology prescreening technology for detection of diabetic retinopathy, cataract, glaucoma, cornea problems and refractive errors.
  • Tissue engineered scaffolds to generate synthetic tracheas.
  • Embolectomy devices
  • Resorbable embolization material for use in interventional radiology and drug delivery.
  • Tissue attachment technology
  • Devices and procedures to improve nasal breathing.
  • Devices for minimally invasive, augmentative or reconstructive mastopexy.
  • Ocular stent for treating age-based vision changes.
  • Ophthalmic device company focusing on age-related macular degeneration (AMD), diabetic retinopathy, retinitis pigmentosa, hemianopia, and glaucoma.
  • Neuroscience-based technology (neuromodulation) for enhancing performance on cognitive tasks, for the healthy and impaired.
  • Portable, ultrasound-based device non-invasive, transcranial diagnosis of stroke.
  • Temporary cardiac pacing as treatment for reversible symptomatic bradycardia.
  • Product to improve treatment of kidney stones and product to reduce pneumonia in intubated patient and ventilated patients in the ICU.
  • Biometric medical device for orthopedic and other diagnostic applications.
  • Technologies for treating urological conditions and disorders.
  • Use of biomaterials in aesthetics for non-surgical temporary & permanent breast and buttock enhancement, facial rejuvination solutions and adipose tissue engineering related therapies.

2013

December

  • Haptic device used in rehabilitation following stroke or neurological injury.
  • Mesh fixation device for soft tissue procedures.
  • Bioimplants are made of bioactive plastic with fibres and they can be used in bone tissue engineering.
  • Biodegradable sealants and adhesives in surgery.
  • Orthopedic implants.
  • Developing a device that mimics the actions of gastric bypass surgery for the treatment of obesity and Type 2 diabetes.

November

  • Vascular drill to cross chronic total obstructions (CTOs) and facilitate balloon angioplasty and stunting.
  • Custom orthopedic device manufacturer
  • Non-invasive, migraine therapy device
  • Ultrasound-based brain noninvasive physiology measurement of cerebral blood flow and intracranial volumetric wave monitoring.
  • Transcranial magnetic stimulation
  • Device for the management of urinary incontinence.
  • Device to alert diabetics of nocturnal hypoglycemia.
  • Fusion and non-fusion technologies in spine surgery
  • Spine surgical technologies including pedicle screws.
  • Neuromodulation for the treatment of a variety of diseases.
  • 3D, biomaterial-based scaffold for tissue engineering
  • Inflatable retractor for use in laparoscopy.
  • ePTFE valve for right ventricular outflow tract reconstruction
  • Drug delivery devices
  • Hemosstatic technology for moderate to severe bleeding.
  • Developing treatments to prevent intimal hyperplasia and associated vascular access failure in renal dialysis.
  • Sleep apnea treatment device
  • Retinal implants

October

  • Systems for minimally invasive knee implants.
  • Innovative prosthetic socket devices for amputees and technologies for limb salvage surgery.
  • Devices for interventional treatment of cardiovascular disease.
  • System and method for localizing medical instruments during cardiovascular medical procedures.
  • Hemostat/sealant.
  • Surgical instrumentation in gynecology.
  • Percutaneous mitral valve repair.
  • Drug delivery for diabetes and pain management.
  • Non-invasive blood glucose monitor.
  • Thermographic mapping system for temperature monitoring during energy-based surgical procedures.
  • Device to reduce sternal bleeding associated with cardiac surgery.
  • Lightweight and low cost ($299) 12-lead diagnostic ECG device.

September

  • Products for weaning from mechanical ventilation and use for patients with COPD.
  • Undisclosed spine treatment.
  • Left ventricular assist device.
  • Hypothermia device for patients with cardiac arrest, traumatic brain injury, stroke and concussion.
  • Fluorescence-sensor based clinical diagnostics for point of care testing.
  • Transcranial Doppler ultrasound for the diagnosis of traumatic brain injury.

August

  • Lumbar interbody spine fusion
  • Intramedullary rods and other orthopedic implants.
  • Single-use device to prevent postpartum hemorrhage.
  • Minimally invasive treatment for mitral regurgitation.
  • Laparoscopic suture technology.
  • Catheters and stent grafts for percutaneous femoral artery bypass.
  • Fracture fixation and other orthopedic devices.
  • Low cost kyphoplasty technology.
  • Fluorescence-based, non-invasive monitoring of glomerular filtration rate for point-of-care use in nephrology.
  • Lumbar interbody fusion products in spine surgery.
  • Ultrasound-based cardiovascular diagnostics.
  • Technologies to prevent clogged orifices to aid in swallowing, medication delivery.

July

  • Monitoring catheters during minimally invasive (interventional) cardiovascular surgery.
  • Biomatarials for bone regeneration.
  • Adult stem cell-based implant to stimulate bone regrowth.
  • Percutaneously transplanted valve for treatment of congestive heart failure.
  • 3D live, microscopic imaging technology for in vitro and in vivo use.
  • Devices for prevention of nasal MRSA colonization.
  • Undisclosed neuro technology.
  • Devices for treatment of vascular occlusion and embolization.
  • Hypothermia for hypoxic-ischemic brain and spinal cord trauma.
  • Transcatheter interarterial shunt for treatment of diastolic heart failure.

June

  • Implantable electrospun neurosurgical meshes and tools.
  • Undisclosed technology for the treatment of aneurysm.
  • Catheter-based, self-expandable device to restore vessel/duct patency in peripheral vascular, neurology, cardiology and women's health applications.
  • Ultrasound guidance for interventional procedures.
  • Undisclosed medical technology development. Affiliated with Excelleration Partners.
  • Technologies for hip replacement.
  • Angiography catheters, others.
  • Neural interface research products and technologies.
  • Hip and knee implants.
  • Surgically implanted, invisible hearing aid device.
  • Undisclosed medical technology relating to allografts.
  • Developing "generic" versions of medical technology.

May

  • Devices in interventional neuroradiology including for treatment of aneurysm.
  • Device for the removal of hemorrhoids.
  • Undisclosed medical technology.
  • Medical device company focused on the treatment of prostate cancer.
  • Retinal imaging test for the detection and diagnosis of Alzheimer's Disease.
  • Non-immunogenic xenograft heart valves.
  • Visualization in orthopedic, spine and sports medicine procedures.
  • Minimally invasive retractor for use in spine surgeries (micro-endoscopic discectomies).
  • Spinal cord stimulation for pain management
  • Spinal implant with sensor.

April

  • Laser-based detection of metastatic cancer cells.
  • Ultrasound therapeutics.
  • Detection of concussion.
  • Orthopaedic implants
  • Spine surgery implants including interspinous process spacers.
  • Technologies in ophthalmology.
  • Surgical implants including for hernia repair.
  • Stomal management solutions.
  • Ophthalmic drug delivery
  • Device for the treatment of fecal impaction.
  • Developing low level light therapy for a variety of medical applications.
  • Device to prevent wound infections.
  • Targeted delivery of fluids including drugs and contrast media.
  • Implants for orthopedics, spine and trauma.
  • Various medical devices, including a device to assist laparoscopic surgery and pain management device.
  • Intraoperative nerve monitoring
  • Treatment of peripheral artery disease.
  • Surgical instrumentation.
  • Minimally invasive device to treat collapsed nasal valves.
  • Minimally invasive treatment for venous reflux disease

March

  • Organ-specific stem and progenitor cells for use in research and therapeutic application, including stem cell transplants for lymphoma and leukemia.
  • Egg precursor cells for the treatment of infertility.
  • Polymer-based adhesive tissue tape for use as a surgical sealant.
  • Devices that are visible yet safe in radiofrequency and magnetic resonance fields.

February

  • Respiratory monitoring devices, such as a "sleep sensors" shirt to enable less invasive monitoring for apnea or other respiratory conditions.
  • Endoscopic, minimally-invasive harvesting of veins used for coronary artery bypass grafting.
  • Ophthalmology diagnostics; binocular device for eye exams.
  • Device-based treatment for respiratory disease.
  • Undisclosed ophthalmology technology.
  • Catheter-based medical devices for the treatment of cardiovascular disease
  • Extracorporeal rotary blood pump system designed to increase eligibility for the arteriovenous fistula (AVF) vascular access site for hemodialysis and to increase AVF maturation success

January

  • Surgical tools for arthroscopic procedures.
  • Fractional flow reserve guidewire method to obtain FFR measurements during coronary catheterization procedures.
  • Technology to ensure accurate intraoperative placement of hip and knee implants.
  • Neurological diagnostics to measure biomarkers, regulate drug dosage, others.
2012

December

  • Device-based treatment of congestive heart failure.
  • Clamping device to control bleeding in trauma.
  • Tissue matrix composition for tissue regeneration and wound care.
  • Spinal pain relief devices.
  • Wireless remote arrhythmia monitoring and diagnosis.
  • Undisclosed

November

  • Tissue regeneration technologies for non-invasive skin care.
  • Biomaterials supplied to medical device and pharma manufacturers
  • Trans-reflective fetal EKG.
  • Surgical instrumentation.
  • Undisclosed medical technology (The Foundry)
  • Technologies for autologous tissue collection.
  • Stem cell therapy.
  • Novel, implantable ring to prevent parastomal hernia in abdominal surgery.
  • Transcatheter repair of mitral valve regurgitation.
  • Synthetic cartilage implant for treatment of osteoarthritis or cartilage damage.

October

  • Device to assist in early detection of melanoma.
  • Small molecules for skeletal tissue regeneration.
  • Intubation device.
  • Device for the point-of-care treatment of chronic central pain.
  • Technologies for detection of perforated bowel.
  • Prosthetic heart valve technology.
  • Catheter-based approach to carotid body modulation for treatment of sympathetic nervous system-mediated disease.
  • Sheaths, snares and other devices in interventional cardiology.
  • Device for non-invasive and reversible treatment of presbyopia.
  • Drill device to reduce complications in orthpedic and spine surgery.
  • System for evacuation of surgical smoke.
  • Minimally invasive technologies for the treatment of stroke.
  • Surgical device technology.
  • Robotic system for use in spine surgery.

September

  • Provides medical device design and development services, such as for hemostasis sealing device for use during interventional catheterization procedures.
  • Device for the treatment of hypertension.
  • Joint venture between DuPont and Royal DSM N.V. to develop surgical sealants, adhesion barriers and tissue adhesives.
  • 3D imaging, flow and pressure in cardiac diagnostics for heart failure.
  • Products for trauma including clamp to address massive hemorrhage.
  • Glucose monitoring in diabetes.
  • Pulmonary therapeutics including positive airway pressure devices.
  • Technology for incisionless bypass in gastrointestinal surgery.
  • Device to facilitate the removal of cataracts
  • Device to improve outcomes following lumbar discectomy in spine surgery.
  • Subcutaneous drug delivery system.
  • Device to reduce patient radiation exposure during diagnostic and therapeutic procedures.
  • Tissue regeneration for wound management.
  • Device for diagnosis and surgical treatment of urinary incontinence.
  • Electroporation for delivery of cytokines in cancer treatment.
  • Synthetic bone materials.
  • Device technologies for central venous access.
  • Device to facilitate neurosurgery.
  • Device to facilitate endotracheal intubation
  • Synthetic, nanofabricated surgical mesh being developed initially as a dural substitute for use in neurosurgical procedures.
  • Synthetic bone graft substitutes
  • Technology for minimally invasive abdominal surgery.
  • Advanced and intuitive methods for the visualization and control of surgical instruments.
  • Tools and technologies for minimally invasive procedures.

August

  • Percutaneous treatment of mitral valve disease.
  • Hyperthermia treatment of cancer.
  • Neurostimulators for pain management.
  • Wound healing products based on a proprietary polymer technology.
  • Debridement of toenails in diabetic and other populations.
  • Decision support tool to predict patients' blood glucose profile and enable user-driven changes to normalize blood glucose levels.
  • Developing devices for mitral valve repair.
  • Magnetically compression anastomosis as an alternative to surgical staplers.
  • Patient positioning for surgery based on peripheral nerve stimulation.
  • Hemodynamic monitor designed for high-risk patients in the OR and ICU.
  • Hysteroscopic morcellator to remove uterine fibroids.
  • Device for compression anastomosis in colorectal surgery.
  • EEG and ECG devices for monitoring respiratory and cardiovascular function.
  • Device to monitor and predict post-operative ileus after abdominal surgery.
  • Treatment for fecal incontinence
  • Device for treatment of female urinary incontinence.
  • Device to apply gaseous nitric oxide to treat chronic diabetic foot ulcers.
  • Biotech developing small molecules and antibodies for treatments in vascular disease and enhancement of wound healing.
  • Nanotechnology based rapid diagnosis of bacterial infection.

July

  • Laser-based detection of metastatic cancer cells.
  • Ultrasound therapeutics.
  • Detection of concussion.
  • Orthopaedic implants
  • Spine surgery implants including interspinous process spacers.
  • Technologies in ophthalmology.
  • Surgical implants including for hernia repair.
  • Stomal management solutions.
  • Ophthalmic drug delivery
  • Device for the treatment of fecal impaction.
  • Developing low level light therapy for a variety of medical applications.
  • Device to prevent wound infections.
  • Targeted delivery of fluids including drugs and contrast media.
  • Implants for orthopedics, spine and trauma.
  • Various medical devices, including a device to assist laparoscopic surgery and pain management device.
  • Intraoperative nerve monitoring
  • Treatment of peripheral artery disease.
  • Surgical instrumentation.
  • Minimally invasive device to treat collapsed nasal valves.
  • Minimally invasive treatment for venous reflux disease

June

  • Regenerative medicine company developing tissue scaffolds
  • Technology to clean laparoscopic lenses
  • Smartphone-enabled otoscope for remote diagnosis of pediatric ear infections
  • Medtech startup company that has developed novel surface modification technologies to treat dental/orthopedic implant failures
  • Electrodes for applying pulsed electric fields to skin lesions
  • Technologies to facilitate minimally invasive, laparoscopic surgery including hysterectomy
  • Device treatments for cerebral aneurysms
  • Handheld device to provide early detection of amblyopia and strabismus
  • Infrared technology used adjectively with surgical tools to detect accidental damage to blood vessels
  • Patient positioning systems for the orthopedic surgical suite

May

  • Products to eliminate preventable contamination during invasive medical procedures
  • Arrhythmia mapping catheters
  • Electrophysiology (EP) recording systems for the treatment of atrial fibrillation
  • Reusable surgical trays
  • Biodegradable implant for treatment of stress urinary incontinence
  • Foam device to stabilize and position patients for surgical procedures
  • Disposable devices for the microsurgical treatment of ophthalmic diseases
  • Surgical simulation technology for spine surgery
  • Intraoperative nerve monitoring
  • Preventive surgical technology to treat the risk of hip fracture

April

  • Less invasive interventional products to treat patients with hemorrhagic stroke
  • Proximal femur fracture fixation
  • Minimally invasive, low cost surgery such as for prostatectomy
  • Fiber optic catheter for removal of tumors and delivery of drugs, including for lung cancer
  • Implant polymer for bone and vascular lesions

March

  • Minimally invasive correction of hallux valgus
  • Devices for the treatment of venous disease
  • Undisclosed medical device technologies
  • Motion- and depth-sensing device for use in surgical navigation
  • Device to facilitate insertion of intrauterine device for birth control
  • Undisclosed medical technologies
  • Developing nanoparticcles for use in ophthalmology

February

  • Undisclosed medical technology
  • Regenerative bandage for the eye that absorbs, dissolves and rapidly heals wounds
  • Cryoablation for chest and airway applications
  • Cervical and lumbar prosthetic disc replacement devices
  • Regenerative medicine based on stromal vascular fraction derived from adult adipose tissue

January

  • Annuloplasty ring for mitral/tricuspid valve repair
  • Microinjection technology for ophthalmic drug delivery
  • Intervertebral implants
  • Undisclosed technology for the treatment of obstructive sleep apnea
  • Technology to enable office-based myringotomy tube procedures
  • Hydrogel technology for the prevention of post-surgical adhesions
  • Organ preservation and transport systems for transplant organs
  • Obesity device technology
  • Endovascular stapling system
  • Device for the treatment of scoliosis in children
  • Drug delivery technology
  • Cannulas and other instruments for use in liposuction and other cosmetic procedures
  • Wound management products including protegodome, a hard, dome-shaped bandage to protect wounds from impact

2011

December

  • Ablation technologies
  • Tissue and organ regeneration
  • Intervertebral implants
  • Pediatric medical and surgical devices
  • Technologies to measure vascular and other body lumen
  • Pancreatic cell-based treatment for diabetes
  • Focused x-rays for radiation therapy with reduced exposure times and adverse collateral tissue effects
  • Obesity treatment device based on reducing stomach capacity
  • Instruments for wound closure

November

  • Glucose monitoring using test strip that connects to smartphones
  • Hemostasis device for use with vascular access in dialysis
  • Transcutaneous near field communications chip for tracking implants
  • Peripheral intravenous (PIV) fluid/medication delivery systems
  • Hemostatic gauze compression bandage incorporating salmon-derived proteins
  • Instruments for office-based hysteroscopy
  • Focused x-rays for radiation therapy with reduced exposure times and adverse collateral tissue effects
  • Therapeutic cooling in the spinal cord.
  • Technologies for vascular access
  • Regenerative medicine company developing products for skin, hair and nails
  • In situ formation of surgical implants
  • Orthopedic implant prostheses

October

  • Kidney stone retention and retrieval devices.
  • Developing a novel class of compounds for treatment of cardiovascular diseases and metabolic syndrome by exploiting novel biology, associated with mitochondria biogenesis and stabilization.
  • Undisclosed medical technology
  • Minimally invasive spinal implant to stabilize spine and minimize twisting that can cause back pain.
  • Stroke detection and other products in neurophysiology assessment.
  • Devices to monitor gastrointestinal bleeding and related diseases.
  • Antimicrobial materials
  • Drug-eluting implant to reduce risk of lung cancer recurrence.
  • Bioabsorbable drug-eluting stent using novel biomaterials, drug and drug delivery technology.
  • Orthopedic biologics.
  • Bioresorbable scaffold for treating occlusive disease in the superficial femoral artery.
  • Patient-controlled device that helps patients recover from knee surgery.
  • Device that stimulates production of natural tears for patients with dry eye disesse.
  • Left ventricular assist devices.

September

  • Hydrogel-based tissue expanders
  • Systems to prepare tissue for prosthetic implants and grafts.
  • Implants for internal compression or distraction of, for example, bone fractures, fusions, and osteotomies.
  • Devices for heart and vascular, initially developing a catheter-delivered heart valve.
  • Imaging and microfluidics based system to detect cancer.
  • Developing system for detecting pressure-induced ischemia to assist in prevention and treatment of pressure ulcers.
  • Fentanyl iontophoretic transdermal drug delivery system.
  • Implants and other devices for treatment of injured or damaged shoulders.
  • Implants for reducing intraocular pressure
  • Minimally invasive fracture fixation systems to be used in load bearing fractures.
  • Developing an intragastric implant for treatment of obesity and diabetes.

August

  • Surgical technologies
  • Tissue healing and hemostasis
  • Surgical clamps for partitioning the stomach in bariatrics
  • Augmented reality for real-time visualization of diagnostic imaging during surgery.
  • Endoscopic camera system
July

  • Hand-held diagnosis of coronary artery disease.
  • Low field magnetic stimulation for neuromodulation in psychiatric and neurological disorders.
  • Thermal based ablation device
  • Technologies for interventional endoscopic procedures.
  • Stealth medical technology company. Principal has degree in glass science.
  • Cold plasma for accelerating wound healing, and other applications.
  • Tissue guided surgery in unicompartmental knee arthoplasty
  • Minimally invasive surgery of the sinuses via tear duct access.
  • Synthetic materials to support tissue regeneration for wound healing, bone regeneration, cartilage repair, stem cell therapy and dermal fillers.
  • Surgical technologies, including device for use in bariatrics (malabsorption).
  • New dosing technology for insulin in treatment of diabetes.
June

  • Undisclosed medical devices
  • Aortic valve implantation system
  • Percutaneous transcatheter closure of patent foramen ovale
  • Undisclosed medical technology
  • Undisclosed medical products (founders have backgrounds in antimicrobial products and infection control)
  • Technologies for the ablation of vascular occlusions
  • Undisclosed surgical technology
  • Portable x-ray
  • MRI imaging for lung disease, cancer, neuroimaging, and inflammatory conditions
  • Dialysis in end-stage renal disease via access to interstitial fluid
  • Aortic valve

May

  • Neuromodulation for major depressive disorder and other neurological disorders.
  • Developing bioactive bone graft material.
  • Percutaneous valve repair/replacement technology for treatment of mitral valve regurgitation.
  • Incision welding using cold plasma device.
  • Lipid-focused therapeutics
  • Bone graft materials.
  • Bioactive glass biomaterial as bone graft substitute.
  • Tissue fixation technology.
  • Technology to localize nerves during surgical procedures.

April

  • Electrospun silk materials for wound dressings.
  • Intra-aortic balloon pump.
  • Pressure management devices used during access procedures to minimize injury.
  • Tissue engineered scaffolds for use in orthopedics.
  • Undisclosed technology in minimally invasive surgery.

March

  • Clip and closure system as for an aperture in a vessel wall.
  • Surgical devices including for vascular surgery.
  • Arrhythmia mapping technology.
  • Undisclosed orthopedic (hip) technology.
  • Drug delivery during abdominal surgery to reduce post-operative pain and formation of adhesions.
  • Catheter technologies.
  • Products for interventional medicine, including a biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications.
  • Non-invasive technology for treatment of atherosclerosis.
  • Device for treatment of lower urinary tract symptoms due to benign prostatic hypertrophy (BPH).

February

  • Novel devices for treating lung diseases.
  • Cleveland Clinical spin-off company, developing a transcatheter mitral valve.
  • Neuromodulation for obesity.
  • Undisclosed technology (stealth medtech company).
  • New portfolio company of Versant Ventures.
  • Technology to expand skin for skin grafts.
  • Photochemical tissue bonding for wound closure.
  • Device to detect lung pathologies.
  • Products to assist laparoscopic surgery.
  • Percutaneously delivered mitral valve to augment rather than replace the native mitral valve.
  • Minimally invasive spine surgery treatment for scoliosis.

January

  • Nanobiotechnology company developing filtration system to remove cancerous cells and pathogens from bodily fluids.
  • Device for office/outpatient treatment of finger joint disorder.
  • Real-time in vivo pathology based on optical coherence tomography.
  • Bone graft substitutes
  • Orthopedic implants
  • Undisclosed technology (stealth medtech company)
  • Implantable drug infusion pumps for treatment of brain-related conditions (e.g., epilepsy).
  • Beating heart access and closure system for cardiovascular surgery.
  • Transcatheter percutaneous mitral valve repair.
  • Drug-free device to reduce pain of injections.
  • Steerable guidewire technology.
  • Embolic protection device.
  • Developing obesity device (gastric volume reduction) technology.
  • Stealth company focusing on diabetes and obesity.

2010

December

  • Nano-encapsulated drug delivery in coronary artery applications.
  • Surgical instrumentation including, for example, staple delivery
  • External fixation in orthopedics
  • Ophthalmic drug delivery
  • Interspinous fusion cages

November

  • Medical and surgical instruments.
  • Device to enable confirmation of endotracheal intubation.
  • Aortic valve insertion system.
  • Orthopedic surgical instruments.
  • Surgical and medical instruments.
  • Vascular closure device technologies.
  • Orthopedic tissue regeneration.
  • Novel endoscopic surgical devices.
  • Treatment of lower urinary tract symptoms due to benign prostatic hypertrophy.

September/October

  • Automated breast ultrasound system to complement mammography.
  • Systems for concentration of autologous adult stem cells applied in surgical approaches to orthopedics.
  • Novel devices for treating lung diseases.
  • Tendon, ligament and soft tissue repair.
  • Undisclosed medical technology from previous founder of Opus Medical, Inc.
  • Implantable device to detect onset of atrial fibrillation and chronic heart failure.
  • Incisionless bariatric surgery device.
  • Silk-based biomaterial platforms for tissue repair and orthopedic applications.
  • Pediatric catheters
  • Device for treatment of chronic vein insufficiency.
  • Sutureless heart valve prostheses.
  • Cryoablation in reproductive medicine.
  • Wound closure technology.
  • Visualization during urinary catheterization.

August

  • Surgical guidewire apparatus.
  • Development stage medical device company.
  • Spinal implant technologies
  • Orthopedic implants

June/July

  • Undisclosed orthopedic device technology.
  • Less invasive pericardial access for treatment of cardiac arrhythmia.
  • Medical technology company
  • Surgical instrumentation
  • Laser technology applied to tissue closure, other applications.
  • Minimally invasive surgical technology

May

  • Single incision laparoscopic surgery and natural orifice transluminal endoscopic surgery.
  • Medical device development company.
  • Surgical instrumentation and osteogenic biomaterials for spine surgery.
  • Clinical diagnostics including a noninvasive prenatal diagnostics.
  • Laparoscopic surgical instrumentation.
  • Ultrasonic breast cancer detection device.
  • Technologies for tendon, ligament and soft tissue repair.
  • Cryogenic ablation system
  • Bone fracture fixation.
  • Laser ablation technologies via dynamic laser pulse system
  • Intramedullary repair system for vertebra fractures

April

  • Technologies in podiatry.
  • Device for treatment of obstructive sleep apnea
  • Device treatment of osteoarthritis.
  • Device for revascularization of occlusions.
  • Device to stabilize the spinal disc as treatment for degenerative disc disease.
  • Developing implantable device for treatment of gastroesophageal reflux disease (GERD).
  • Medical devices to improve the safety and efficiency of laparoscopic surgery.
  • Tools for less invasive spinal surgery.
  • Devices for spine surgery.
  • Pedicle screw augmentation in the osteoporotic spine.
  • Coronary stent technologies.

March/February

  • Novel optical scalpel for ultra-precise ophthalmic laser surgery
  • Wound healing technology based on choroid plexus proteins.
  • Osteobiologics
  • Creating "natural bionanomatrix coating technologies for medical devices and clinical problems in cardiovascular disease."
  • Needleless vascular access for dialysis
  • Stem cell coatings for medical devices and implants.
  • Neuromodulation for urinary incontinence.
  • Motion preservation and percutaneous technologies in spine surgery.
  • New platform technology for vials, syringes, autoinjectors and other drug delivery devices.
  • Dissolution of arterial plaques via elevation of bile salts.
  • Developing an innovative ultrasound platform technology for medical applications.
  • Laparoscopic instrument for repair of ventral hernias.
  • Catheter-based drug delivery for treatmetn of vascular disease and restenosis.
  • Late stage medical device acquisitions.

January

  • Incubator company from shifamed.com
  • Developing minimally invasive therapies for end stage renal disease.
  • Electrical stimulation technology to restore temporary continence control for patients with colostomies.
  • Sonolysis for treatment of vascular thromobus disorders.
  • Undisclosed nanotech medical product development
  • Medical robotics
  • Undisclosed medical technology
  • Tissue welding via cold plasma and albumin.
  • Intravascular medical device coatings containing resveratrol and quercetin
  • Collagen-based implants for soft tissue defects.
  • Drug-device combinations in cardiovascular, renal and GI
  • Endometrial ablation for treatment of abnormal uterine bleeding

2009

December

  • Disposable microchip for handheld (point-of-care) diagnostics.
  • Vascular access device.
  • Technologies to treat pulmonary diseases.
  • Medical device company focused on metabolic disorders.
  • Surgical suture system.
  • Biologically based nanomatrix coating technologies for medical devices.
  • Ultrasound tissue ablation technology to non-invasively destroy tumors and other lesions.
  • Ultrasound-based brain stimulation device for Parkinson's, Alzheimer’s disease, epilepsy, tinnitus, obsessive-compulsive disorder, obesity and chronic pain.

November

  • Scaffold for regeneration of functional bone tissues.
  • Autologous, adipose-derived stem cells for treatment of traumatic brain injury and chronic obstructive pulmonary disease.
  • Device company developing technologies to improve the safety and efficiency of chemotherapy.
  • Developing stem cell therapies.
  • Devices to locate and protect nerves during surgery.
  • Minimally invasive (endoscopic) spine surgery products.
  • Technologies developed by physicians at a major hospital in a range of areas including imaging, cath lab procedures, fecal incontinence treatment, and others.
  • Robotic system to assist in guidewire procedures.
  • Nanoparticles to stimulate axon regeneration in spinal cord injury.

October

  • Diagnostic imaging in urology and oncology.
  • Endoscopic tissue management technology.
  • Esophageal monitoring device to replace peripheral artery catheter.
  • Products for treatment of fecal incontinence and GERD.
  • Surgical instrumentation to reduce trauma of surgery.
  • Suction device for use in sleep breathing disorders.
  • Fully absorbable coronary stent.
  • Drug-eluting balloons.

September

  • Medical devices to enable deployment of vascular implants
  • Tibial prosthesis
  • Tools for performing less invasive orthopedic joint procedures.
  • Technologies in in vitro fertilization (IVF)
  • Medical device company developing antimicrobial materials for treatment of infections disease.
  • Minimally invasive device technologies.
  • Extracellular matrices for soft tissue regeneration.
  • Portable home hemodialysis.
  • Intravenously placed electrodes to stimulate the diaphragm as replacement for traditional mechanical ventilation.
  • Photonic based surgical technologies platform.

August

  • Finger-mounted ultrasound probe.
  • Diagnostic and medical device technologies.
  • Device to increase cerebral blood flow in stroke, Alzheimer's and other conditions.
  • Device for the treatment of bowel incontinence. (A Shalon Ventures portfolio company.)
  • Endoscopic treatment for gastric reflux.RF ablation technology for aesthetic applications.
  • Stealth company developing non-spine orthopedic technology

July

  • Pedicle screw replacement in spine surgery
  • Transcatheter treatment of patent foramen ovale and septal defect.
  • Soft tissue fixation technologies to improve the strength and simplicity of the reattachment of soft tissue to bone.
  • Interventional devices for treating GI disorders (fistula closure).
  • Developing for the delivery of epidural anaesthesia.
  • Technology to improve the performance of vascular prostheses; initial application in abdominal aortic aneurysms (AAA).
  • Minimally invasive implant for the treatment of stress incontinence.
  • Novel vena caval filter for preventing pulmonary embolism.
  • Spinal tension band for restriction of motion between vertebrae in spine disorders.
  • Hydrogels for radiation oncology and cancer surgery indications.
  • Undisclosed technology
  • Undisclosed cardiac valve technology.

June

  • Device for the prevention of migration and leakage problems associated with endovascular stent grafts for abdominal aortic aneurysms.
  • Drug delivery technologies for treatment of vascular disease.
  • R&D of spinal products
  • System for detecting endothelial dysfunction as a precursor to cardiovascular disease.
  • Implantable medical device for the treatment of benign prostate hyperplasia.
  • Stent placement system
  • Device for treatment of fractures of the neck of the femur.
  • Develops devices embedded with stem-cell for treatment of acute organ failure.
  • Drug-device products for localized drug delivery.

May

  • Therapeutic cardiovascular devices.

  • Catheter technologies.

  • Undisclosed medical devices.

  • Orthopedic attachment and fixation.

  • Orthopedic joints (hip, knee, shoulder), fracture fixation and other devices.

  • Electromechanical orthopedic implant to alleviate leg and lumbar pain.

  • Percutaneous mitral valve replacement.

  • Femtosecond lasers for cataract surgery

April

  • Intraarterial ventricular assist device.

  • Micro-robotic imaging and surgical device technology to facilitate minimally invasive surgeries.

  • "Cell bandage" technology for repair of damaged knee meniscus.

  • Glucose sensor and regulation technology

March

  • External fixation for leg bone fractures.

  • Devices for minimally invasive spine surgery

  • Device for tissue preservation during orthopedic surgery

  • Nanoparticle-based immunomodulatory drugs.

  • Pharmaceutical preparations for treatment of obesity.

  • Drug-eluting balloons.

  • Implantable shunt for draining fluid, such as for synovial fluid.

  • Undisclosed ophthalmic devices.

  • Proprietary system to assist orthopedic surgeons in the delivery of long bone intramedullary nail implants.

  • Devices in interventional cardiology.

  • Coronary artery augmentation system to prevent need for reoperation of clotted grafts.

  • Bio prosthetic devices including cardiovascular stents.

February

  • Seed stage company within VC firm developing a low profile stent graft for the treatment of abdominal aortic aneurysms (AAA).

  • Stealth medical device company

  • Soft tissue regeneration of the anterior cruciate ligament (ACL) of the knee.

  • Near infrared-based venous imaging system\embolic protection device

  • Bioactive, polymer materials and coatings for medical devices to improve biocompatibility, safety, and improve MRI compatibility.

Dec/Jan

  • Orthopedic implants to aid in fracture repair.

  • Radio-frequency surgical applications in orthopedics.

  • Autologous fluid concentrator

  • Intraoperative nerve location and protection device.

  • Peripheral nerve stimulation for treatment of post-stroke shoulder pain.

  • Biocompatible, thermoplastic materials for osteosynthesis

  • Pain management

  • Minimally invasive spine technologies

  • Novel treatments for gastrointestinal disorders.

  • Innovative treatment for patients with osteoarthritis.

  • Image-guided laparoscopy system

  • Orthopedic implants

  • Provider of products for the orthopaedic device market, formed via merger

  • Developing device to diagnose abnormal joint conditions via ultrasound.

  • Intraoperative nerve location and protection device

  • Medical device to prevent surgical site infections in orthopedic and spinal surgeries

  • Surgical dressings

  • Spinal implant manufacturer

  • Surgical irrigation and retraction systems

  • Autologous fluid concentrator

  • Nanotechnology biomaterials company developing angiogenic materials for use in wound management, treatment of ischemic heart disease, others

  • Devices based on piezoelectric, magnetorestrictive and shape memory materials technologies, including a sonicator and an ophthalmic surgical device

  • Medical device company backed by Flagship Ventures, Polaris Venture Partners and Third Rock Ventures

  • Peripheral nerve stimulation for treatment of post-stroke shoulder pain

  • Polymer-based absorbable surgical hemostats

2008

November

  • Biomaterials for use in aesthetic surgery

  • New vascular devices for use on patients that undergo procedures with a high risk of blood vessel blockage

  • Treatments and diagnostics for orthopedics

  • Devices for cardiac surgery, including a device for performing structured sternal incisions

  • Handheld diagnostic device detecting cancer cells via fluorescing enzyme, performed following tumor removal to detect residual cancer

  • Ambulatory cardiac monitoring

  • Minimally invasive RF tissue welding technology for use in lung resection and biopsy

  • Innovative technologies to treat heart valve disease

  • Imaging capsule long-term monitoring of bladder cancer

October

  • Laser devices to "weld" biological tissues together for wound closures.

  • Drug-coated urinary and other catheters and stents that are designed to prevent or treat scar tissue.

  • Artificial heart technologies.

  • Heart pumps.

  • Compliant balloon technologies.

  • Device for mitral valve repair without need for sternotomy.

  • Pharmaceutical treatments for ischemia and vascular disease, focused on peripheral artery disease.

  • Non-polymeric drug eluting stent

  • Device technology in diabetes management.

  • Medical device inflatables, including devices for biological navigation such as in support of colonoscopy and other endoscopy.

  • Minimally invasive products for motion-preserving spine surgery.

  • Minimally invasive treatment of vertebral compression fractures.

  • Minimally invasive treatments for removing varicose veins.

  • Drug-coated angioplasty for coronary and peripheral applications

  • Fully implantable artificial heart

September

  • Recombinant proteins and cells for inter vertebral disc cell regeneration

  • Non-hydrogel polymer used to stimulate tissue growth in dental/orthopedic applications

  • Biomaterials and biologics for repair of bone and cartilage

  • Portable endoscopic imaging

  • Device treatments for restless leg syndrome (RLS)

  • Disposable steerable surgical instrumentation for arthroscopy

  • Technologies to restore spinal disc function

  • Embolic protection system


 

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